DSpace Repository

Association of Systemic Lupus International Collaborating Clinics Frailty Index With Damage in Systemic Lupus Erythematosus Patients: Results From a Multiethnic, Multicenter US Cohort of Patients With Lupus

Show simple item record

dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Dubey, Jyoti
dc.contributor.author McGwin, Gerald, Jr.
dc.contributor.author Reveille, John D.
dc.contributor.author Vila, Luis M.
dc.contributor.author Alarcón, Graciela S.
dc.date.accessioned 2022-11-15T23:04:42Z
dc.date.available 2022-11-15T23:04:42Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12620
dc.description.abstract Objective. To evaluate the association between the Systemic Lupus International Collaborating Clinics frailty index (SLICC-FI) and damage accrual in systemic lupus erythematosus (SLE) patients.Methods. Patients from the multiethnic, multicenter LUpus in MInorities, NAture versus nurture (LUMINA) cohort were included. Damage was ascertained with the SLICC/American College of Rheumatology Damage Index (SDI) at last visit (range 0-51). The first visit in which the SLICC-FI score could be derived was considered as the baseline (range 0-1). Univariable and multivariable negative binomial regression models were performed to determine the association between the baseline SLICC-FI score (per 0.05 increase) and the change in the SDI score (difference between last and baseline SDI score), adjusted for sex, age at diagnosis, ethnicity, insurance, prednisone daily dose, and antimalarial and immunosuppressive drug use at baseline. Age and sex were included a priori in the multivariable model; the other variables were included if they reached P < 0.10 in the univariable models.Results. Of the 503 patients included, 454 (90.3%) were female, with a mean +/- SD age of 37.1 +/- 12.5 years at diagnosis. The mean +/- SD baseline SLICC-FI score was 0.26 +/- 0.06. The mean +/- SD baseline SDI score was 0.6 +/- 1.0, and the mean +/- SD change in the SDI score was 1.9 +/- 2.2. Higher SLICC-FI scores at baseline (per 0.05 increase) were associated with greater damage accrual in the multivariable model after adjustment for possible confounders (incidence rate ratio 1.20 [95% confidence interval 1.08-1.33], P = 0.0015).Conclusion. The SLICC-FI is associated with damage accrual in SLE patients from a multiethnic cohort, supporting the importance of this index in the evaluation of SLE patients, combining several aspects of their disease. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Arthritis Care and Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Systemic Lupus International en_US
dc.subject Systemic Lupus Erythematosus Patients en_US
dc.subject Multiethnic en_US
dc.title Association of Systemic Lupus International Collaborating Clinics Frailty Index With Damage in Systemic Lupus Erythematosus Patients: Results From a Multiethnic, Multicenter US Cohort of Patients With Lupus en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/acr.24878
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 2151-4658


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics