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Health-Related Quality of Life in Adults with Adolescent- and Adult-onset Systemic Lupus Erythematosus: A Longitudinal Study of a Multiethnic US Cohort (LUMINA LXXXIV).

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dc.contributor.author Borgia, R. Ezequiel
dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Vila, Luis M.
dc.contributor.author Reveille, John D.
dc.contributor.author McGwin, Gerald Jr.
dc.contributor.author Alarcón, Graciela S.
dc.date.accessioned 2022-11-15T23:04:42Z
dc.date.available 2022-11-15T23:04:42Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12621
dc.description.abstract BACKGROUND/PURPOSE: The long-term impact of childhood-onset systemic lupus erythematosus on Health-related Quality of Life (HRQoL) in adult SLE patients in comparison to those with adult-onset SLE is unknown. We aim to examine and compare HRQoL trajectories in adults with adolescent- and adult-onset SLE.METHODS: Patients enrolled in the LUMINA cohort were included. Adolescent-onset SLE were those diagnosed <24years of age, and adult-onset SLE otherwise. Sociodemographic, clinical, medications, behavioral/psychological and functioning data were obtained. Longitudinal trajectories of the physical component (PCS) and the mental component (MCS) SF-36 summary scores were compared between the groups using a linear mixedmodel accounting for time-dependent and independent covariates.RESULTS: 470 SLE patients were included (95 adolescent-onset SLE and 375 adult-onset SLE). The mean age at diagnosis was 19.7years (SD: 2.8) in the adolescent group and 39.3years (SD: 11.0) in the adult group. Baseline PCS was higher (better physical functioning) in adolescent- when compared to adult-onset SLE (38.9 vs 34.3 respectively, p<0.001); however, the baseline MCS scores was comparable between the groups (41.4 vs 40.5 respectively, p=0.53). The HRQoL improved equally in both groups with no statistically significant difference within and between the groups (last PCS and MCS mean scores: 43.9 and 45.3 in adolescent-onset SLE; 38.1 and 43 in adult-onset SLE respectively).CONCLUSIONS: Adults with adolescent-onset SLE exhibited better physical functioning when compared with the adult SLE group despite more severe disease; noteworthy, HRQoL was below the general US population despite clinically meaningful improvement in HRQoL over time in both groups. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Arthritis Care and Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Quality of Life en_US
dc.subject Adults en_US
dc.subject Adolescent en_US
dc.subject Systemic Lupus Erythematosus en_US
dc.title Health-Related Quality of Life in Adults with Adolescent- and Adult-onset Systemic Lupus Erythematosus: A Longitudinal Study of a Multiethnic US Cohort (LUMINA LXXXIV). en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/acr.25006
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 2151-4658


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