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Association Between Race/Ethnicity and COVID-19 Outcomes in Systemic Lupus Erythematosus (SLE) Patients from the United States: Data from the COVID-19 Global Rheumatology Alliance.

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dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Seet, Andrea M.
dc.contributor.author Izadi, Zara
dc.contributor.author Montgomery, Anna D.
dc.contributor.author Duarte-Garcia, Ali
dc.contributor.author Gilbert, Emily L.
dc.contributor.author Valenzuela-Almada, Maria O.
dc.contributor.author Wise, Leanna
dc.contributor.author Sparks, Jeffrey A.
dc.contributor.author Hsu, Tiffany Y.-T.
dc.contributor.author D'Silva, Kristin M.
dc.contributor.author Patel, Naomi J.
dc.contributor.author Sirotich, Emily
dc.contributor.author Liew, Jean W.
dc.contributor.author Hausmann, Jonathan S.
dc.contributor.author Sufka, Paul
dc.contributor.author Grainger, Rebecca
dc.contributor.author Bhana, Suleman
dc.contributor.author Wallace, Zachary
dc.contributor.author Jacobsohn, Lindsay
dc.contributor.author Strangfeld, Anja
dc.contributor.author Mateus, Elsa F.
dc.contributor.author Hyrich, Kimme L.
dc.contributor.author Gossec, Laure
dc.contributor.author Carmona, Loreto
dc.contributor.author Lawson-Tovey, Saskia
dc.contributor.author Kearsley-Fleet, Lianne
dc.contributor.author Schaefer, Martin
dc.contributor.author Machado, Pedro M.
dc.contributor.author Robinson, Philip C.
dc.contributor.author Gianfrancesco, Milena
dc.contributor.author Yazdany, Jinoos
dc.date.accessioned 2022-11-15T23:04:42Z
dc.date.available 2022-11-15T23:04:42Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12622
dc.description.abstract OBJECTIVE: To determine the association between race/ethnicity and COVID-19 outcomes in individuals with systemic lupus erythematosus (SLE).METHODS: Individuals with SLE from the United States with data entered into the COVID-19 Global Rheumatology Alliance (GRA) registry between 24 March 2020 and 27 August 2021 were included. Variables included age, sex, race and ethnicity (White, Black, Hispanic, other), comorbidities, disease activity, pandemic time period, glucocorticoid dose, antimalarials, and immunosuppressive drug use. The ordinal outcome categories were: not hospitalized, hospitalized with no oxygenation, hospitalized with any ventilation or oxygenation, and death. We constructed ordinal logistic regression models evaluating the relationship between race/ethnicity and COVID-19 severity, adjusting for possible confounders.RESULTS: We included 523 patients; 486 (90.7%) were female and the mean age was 46.6 (SD: 14.0) years. Three hundred and fifty-eight (74.6%) patients were not hospitalized; 40 (8.3%) patients were hospitalized without oxygen, 64 (13.3%) patients were hospitalized with any oxygenation and 18 (3.8%) died. In a multivariable model, Black [OR=2.73 (1.36-5.53)] and Hispanic [OR=2.76 (1.34-5.69)] individuals had higher odds of more severe outcomes than White individuals.CONCLUSIONS: Black and Hispanic individuals with SLE experienced more severe COVID-19 outcomes, which is consistent with findings in the US general population. These results likely reflect socioeconomic and health disparities and suggest that more aggressive efforts are needed to prevent and treat infection in this population. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Arthritis Care and Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Race en_US
dc.subject Ethnicity en_US
dc.subject COVID-19 en_US
dc.subject Systemic Lupus Erythematosus en_US
dc.subject SLE en_US
dc.subject United States en_US
dc.subject Rheumatology en_US
dc.title Association Between Race/Ethnicity and COVID-19 Outcomes in Systemic Lupus Erythematosus (SLE) Patients from the United States: Data from the COVID-19 Global Rheumatology Alliance. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/acr.25039
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 2151-4658


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