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Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium

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dc.contributor.author de Erausquin, Gabriel A.
dc.contributor.author Snyder, Heather
dc.contributor.author Brugha, Traolach S.
dc.contributor.author Seshadri, Sudha
dc.contributor.author Carrillo, Maria
dc.contributor.author Sagar, Rajesh
dc.contributor.author Huang, Yueqin
dc.contributor.author Newton, Charles
dc.contributor.author Tartaglia, Carmela
dc.contributor.author Teunissen, Charlotte
dc.contributor.author Hakanson, Krister
dc.contributor.author Akinyemi, Rufus
dc.contributor.author Prasad, Kameshwar
dc.contributor.author D'Avossa, Giovanni
dc.contributor.author Gonzalez-Aleman, Gabriela
dc.contributor.author Hosseini, Akram
dc.contributor.author Vavougios, George D.
dc.contributor.author Sachdev, Perminder
dc.contributor.author Bankart, John
dc.contributor.author Mors, Niels Peter Ole
dc.contributor.author Lipton, Richard
dc.contributor.author Katz, Mindy
dc.contributor.author Fox, Peter T.
dc.contributor.author Katshu, Mohammad Zia
dc.contributor.author Iyengar, M. Sriram
dc.contributor.author Weinstein, Galit
dc.contributor.author Sohrabi, Hamid R.
dc.contributor.author Jenkins, Rachel
dc.contributor.author Stein, Dan J.
dc.contributor.author Hugon, Jacques
dc.contributor.author Mavreas, Venetsanos
dc.contributor.author Blangero, John
dc.contributor.author Cruchaga, Carlos
dc.contributor.author Krishna, Murali
dc.contributor.author Wadoo, Ovais
dc.contributor.author Becerra, Rodrigo
dc.contributor.author Zwir, Igor
dc.contributor.author Longstreth, William T.
dc.contributor.author Kroenenberg, Golo
dc.contributor.author Edison, Paul
dc.contributor.author Mukaetova-Ladinska, Elizabeta
dc.contributor.author Staufenberg, Ekkehart
dc.contributor.author Figueredo-Aguiar, Mariana
dc.contributor.author Yecora, Agustin
dc.contributor.author Vaca, Fabiana
dc.contributor.author Zamponi, Hernan P.
dc.contributor.author Lo Re, Vincenzina
dc.contributor.author Majid, Abdul
dc.contributor.author Sundarakumar, Jonas
dc.contributor.author Gonzalez, Hector M.
dc.contributor.author Geerlings, Mirjam, I
dc.contributor.author Skoog, Ingmar
dc.contributor.author Salmoiraghi, Alberto
dc.contributor.author Boneschi, Filippo Martinelli
dc.contributor.author Patel, Vibuthi N.
dc.contributor.author Santos, Juan M.
dc.contributor.author Rivera Arroyo, Guillermo
dc.contributor.author Caballero Moreno, Antonio
dc.contributor.author Felix, Pascal
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Arai, Hidenori
dc.contributor.author Yamada, Masahito
dc.contributor.author Iwatsubo, Takeshi
dc.contributor.author Sharma, Malveeka
dc.contributor.author Chakraborty, Nandini
dc.contributor.author Ferreccio, Catterina
dc.contributor.author Akena, Dickens
dc.contributor.author Brayne, Carol
dc.contributor.author Maestre, Gladys
dc.contributor.author Blangero, Sarah Williams
dc.contributor.author Brusco, Luis, I
dc.contributor.author Siddarth, Prabha
dc.contributor.author Hughes, Timothy M.
dc.contributor.author Zuniga, Alfredo Ramirez
dc.contributor.author Kambeitz, Joseph
dc.contributor.author Laza, Agustin Ruiz
dc.contributor.author Allen, Norrina
dc.contributor.author Panos, Stella
dc.contributor.author Merrill, David
dc.contributor.author Ibanez, Agustin
dc.contributor.author Tsuang, Debby
dc.contributor.author Valishvili, Nino
dc.contributor.author Shrestha, Srishti
dc.contributor.author Wang, Sophia
dc.contributor.author Padma, Vasantha
dc.contributor.author Anstey, Kaarin J.
dc.contributor.author Ravindrdanath, Vijayalakshmi
dc.contributor.author Blennow, Kaj
dc.contributor.author Mullins, Paul
dc.contributor.author Pria, Anand
dc.contributor.author Mosley, Thomas H.
dc.contributor.author Gowland, Penny
dc.contributor.author Girard, Timothy D.
dc.contributor.author Bowtell, Richard
dc.contributor.author Vahidy, Farhaan S.
dc.date.accessioned 2022-11-15T23:04:42Z
dc.date.available 2022-11-15T23:04:42Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12623
dc.description.abstract Introduction Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term. Methods This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions. Results Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe. Discussion The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection. Key Points The following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD) The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS-CoV-2 triggers ADRD-like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility. The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under-represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long-term consequences, and trends in cognitive aging, ADRD, and vascular disease. We provide a framework for current and future studies to be carried out within the Consortium.and offers a "green paper" to the research community with a very broad, global base of support, on tools suitable for low- and middle-income countries aimed to compare and combine future longitudinal data on the topic. The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID-19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high-quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Alzheimer's and Dementia. Translational Research and Clinical Interventions
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject cognitive impairment en_US
dc.subject dementia en_US
dc.subject neuropsychiatric sequelae en_US
dc.subject predictors en_US
dc.subject SARS-CoV-2 en_US
dc.title Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/trc2.12348
dc.relation.issn 2352-8737


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