Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium

Blangero, Sarah Williams; Shrestha, Srishti; Hugon, Jacques; Wang, Sophia; Hosseini, Akram; Akinyemi, Rufus; Zwir, Igor; Sagar, Rajesh; Ibanez, Agustin; Ferreccio, Catterina; Siddarth, Prabha; Hughes, Timothy M.; Arai, Hidenori; Sharma, Malveeka; Brugha, Traolach S.; Staufenberg, Ekkehart; Mosley, Thomas H.; Cruchaga, Carlos; Katz, Mindy; Longstreth, William T.; Hakanson, Krister; Ravindrdanath, Vijayalakshmi; Seshadri, Sudha; de Erausquin, Gabriel A.; Mavreas, Venetsanos; Maestre, Gladys; Felix, Pascal; Padma, Vasantha; Pria, Anand; Blangero, John; Santos, Juan M.; Allen, Norrina; Lipton, Richard; Merrill, David; Carrillo, Maria; Weinstein, Galit; Chakraborty, Nandini; Salmoiraghi, Alberto; Blennow, Kaj; Huang, Yueqin; Prasad, Kameshwar; D'Avossa, Giovanni; Mukaetova-Ladinska, Elizabeta; Mors, Niels Peter Ole; Gonzalez-Aleman, Gabriela; Bowtell, Richard; Newton, Charles; Brayne, Carol; Zamponi, Hernan P.; Sundarakumar, Jonas; Gowland, Penny; Valishvili, Nino; Tartaglia, Carmela; Jenkins, Rachel; Caballero Moreno, Antonio; Becerra, Rodrigo; Boneschi, Filippo Martinelli; Panos, Stella; Vavougios, George D.; Snyder, Heather; Girard, Timothy D.; Krishna, Murali; Yecora, Agustin; Gallo López-Aliaga, Carla Maria; Geerlings, Mirjam, I; Kambeitz, Joseph; Sohrabi, Hamid R.; Sachdev, Perminder; Edison, Paul; Figueredo-Aguiar, Mariana; Brusco, Luis, I; Gonzalez, Hector M.; Stein, Dan J.; Laza, Agustin Ruiz; Iyengar, M. Sriram; Kroenenberg, Golo; Lo Re, Vincenzina; Tsuang, Debby; Zuniga, Alfredo Ramirez; Vaca, Fabiana; Rivera Arroyo, Guillermo; Bankart, John; Yamada, Masahito; Mullins, Paul; Skoog, Ingmar; Majid, Abdul; Katshu, Mohammad Zia; Anstey, Kaarin J.; Teunissen, Charlotte; Vahidy, Farhaan S.; Patel, Vibuthi N.; Akena, Dickens; Fox, Peter T.; Wadoo, Ovais; Iwatsubo, Takeshi

dc.contributor.author	de Erausquin, Gabriel A.
dc.contributor.author	Snyder, Heather
dc.contributor.author	Brugha, Traolach S.
dc.contributor.author	Seshadri, Sudha
dc.contributor.author	Carrillo, Maria
dc.contributor.author	Sagar, Rajesh
dc.contributor.author	Huang, Yueqin
dc.contributor.author	Newton, Charles
dc.contributor.author	Tartaglia, Carmela
dc.contributor.author	Teunissen, Charlotte
dc.contributor.author	Hakanson, Krister
dc.contributor.author	Akinyemi, Rufus
dc.contributor.author	Prasad, Kameshwar
dc.contributor.author	D'Avossa, Giovanni
dc.contributor.author	Gonzalez-Aleman, Gabriela
dc.contributor.author	Hosseini, Akram
dc.contributor.author	Vavougios, George D.
dc.contributor.author	Sachdev, Perminder
dc.contributor.author	Bankart, John
dc.contributor.author	Mors, Niels Peter Ole
dc.contributor.author	Lipton, Richard
dc.contributor.author	Katz, Mindy
dc.contributor.author	Fox, Peter T.
dc.contributor.author	Katshu, Mohammad Zia
dc.contributor.author	Iyengar, M. Sriram
dc.contributor.author	Weinstein, Galit
dc.contributor.author	Sohrabi, Hamid R.
dc.contributor.author	Jenkins, Rachel
dc.contributor.author	Stein, Dan J.
dc.contributor.author	Hugon, Jacques
dc.contributor.author	Mavreas, Venetsanos
dc.contributor.author	Blangero, John
dc.contributor.author	Cruchaga, Carlos
dc.contributor.author	Krishna, Murali
dc.contributor.author	Wadoo, Ovais
dc.contributor.author	Becerra, Rodrigo
dc.contributor.author	Zwir, Igor
dc.contributor.author	Longstreth, William T.
dc.contributor.author	Kroenenberg, Golo
dc.contributor.author	Edison, Paul
dc.contributor.author	Mukaetova-Ladinska, Elizabeta
dc.contributor.author	Staufenberg, Ekkehart
dc.contributor.author	Figueredo-Aguiar, Mariana
dc.contributor.author	Yecora, Agustin
dc.contributor.author	Vaca, Fabiana
dc.contributor.author	Zamponi, Hernan P.
dc.contributor.author	Lo Re, Vincenzina
dc.contributor.author	Majid, Abdul
dc.contributor.author	Sundarakumar, Jonas
dc.contributor.author	Gonzalez, Hector M.
dc.contributor.author	Geerlings, Mirjam, I
dc.contributor.author	Skoog, Ingmar
dc.contributor.author	Salmoiraghi, Alberto
dc.contributor.author	Boneschi, Filippo Martinelli
dc.contributor.author	Patel, Vibuthi N.
dc.contributor.author	Santos, Juan M.
dc.contributor.author	Rivera Arroyo, Guillermo
dc.contributor.author	Caballero Moreno, Antonio
dc.contributor.author	Felix, Pascal
dc.contributor.author	Gallo López-Aliaga, Carla Maria
dc.contributor.author	Arai, Hidenori
dc.contributor.author	Yamada, Masahito
dc.contributor.author	Iwatsubo, Takeshi
dc.contributor.author	Sharma, Malveeka
dc.contributor.author	Chakraborty, Nandini
dc.contributor.author	Ferreccio, Catterina
dc.contributor.author	Akena, Dickens
dc.contributor.author	Brayne, Carol
dc.contributor.author	Maestre, Gladys
dc.contributor.author	Blangero, Sarah Williams
dc.contributor.author	Brusco, Luis, I
dc.contributor.author	Siddarth, Prabha
dc.contributor.author	Hughes, Timothy M.
dc.contributor.author	Zuniga, Alfredo Ramirez
dc.contributor.author	Kambeitz, Joseph
dc.contributor.author	Laza, Agustin Ruiz
dc.contributor.author	Allen, Norrina
dc.contributor.author	Panos, Stella
dc.contributor.author	Merrill, David
dc.contributor.author	Ibanez, Agustin
dc.contributor.author	Tsuang, Debby
dc.contributor.author	Valishvili, Nino
dc.contributor.author	Shrestha, Srishti
dc.contributor.author	Wang, Sophia
dc.contributor.author	Padma, Vasantha
dc.contributor.author	Anstey, Kaarin J.
dc.contributor.author	Ravindrdanath, Vijayalakshmi
dc.contributor.author	Blennow, Kaj
dc.contributor.author	Mullins, Paul
dc.contributor.author	Pria, Anand
dc.contributor.author	Mosley, Thomas H.
dc.contributor.author	Gowland, Penny
dc.contributor.author	Girard, Timothy D.
dc.contributor.author	Bowtell, Richard
dc.contributor.author	Vahidy, Farhaan S.
dc.date.accessioned	2022-11-15T23:04:42Z
dc.date.available	2022-11-15T23:04:42Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12623
dc.description.abstract	Introduction Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term. Methods This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions. Results Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe. Discussion The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection. Key Points The following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD) The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS-CoV-2 triggers ADRD-like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility. The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under-represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long-term consequences, and trends in cognitive aging, ADRD, and vascular disease. We provide a framework for current and future studies to be carried out within the Consortium.and offers a "green paper" to the research community with a very broad, global base of support, on tools suitable for low- and middle-income countries aimed to compare and combine future longitudinal data on the topic. The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID-19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high-quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Alzheimer's and Dementia. Translational Research and Clinical Interventions
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	cognitive impairment	en_US
dc.subject	dementia	en_US
dc.subject	neuropsychiatric sequelae	en_US
dc.subject	predictors	en_US
dc.subject	SARS-CoV-2	en_US
dc.title	Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1002/trc2.12348
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.04
dc.relation.issn	2352-8737