Urine H-1-NMR Metabolomics to Discriminate Neurocysticercosis Patients from Healthy Controls: An Exploratory Study

Gonzales, Isidro; Lopez, J. M.; García Lescano, Héctor Hugo; Bustos Palomino, Javier Arturo; Saavedra Pastor, Herbert; Leyva, V. E.; Perez, Erika; Sanchez, Sofia S.; Maruenda, H.; Cysticercosis Working Grp Peru

dc.contributor.author	Lopez, J. M.
dc.contributor.author	Leyva, V. E.
dc.contributor.author	Bustos Palomino, Javier Arturo
dc.contributor.author	Perez, Erika
dc.contributor.author	Sanchez, Sofia S.
dc.contributor.author	Saavedra Pastor, Herbert
dc.contributor.author	Gonzales, Isidro
dc.contributor.author	Maruenda, H.
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	Cysticercosis Working Grp Peru
dc.date.accessioned	2022-12-14T14:25:33Z
dc.date.available	2022-12-14T14:25:33Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12867
dc.description.abstract	The diagnosis of neurocysticercosis (NCC) is principally based on neuroimaging (magnetic resonance imaging or computed tomography), instrumentation that is scarcely available in the rural regions where Taenia solium transmission, primarily occurs due to poor sanitation conditions. Immunological assays for antigen or antibody detection complement the neuroimaging approach. However, no field-applicable assays to diagnose viable NCC or to guide the referral of cases for neuroimaging or for appropriate management are available. We performed an exploratory study on urine and serum samples using 1H-nuclear magnetic resonance (NMR)-based metabolomics to discriminate NCC patients (n = 14) from healthy control subjects (n = 22). Metabolic profiles demonstrated a discrimination between the urines of NCC patients and noninfected control subjects with a moderate predictive accuracy (R2 = 0.999, Q2 = 0.434). NMR metabolomics analysis has been proven useful in depicting biomarkers linked to other infectious diseases, various types of cancer, and other disorders. Our results, albeit preliminary, open a door to the development of better methods for detecting NCC through the identification of biomarkers participating in disturbed metabolic pathways.	en_US
dc.description.sponsorship	Este trabajo fue financiado en el marco del Programa Atracción de Investigadores CIENCIACTIVA por CONCYTEC [número de contrato 008-2017-FONDECYT].	es_PE
dc.language.iso	eng
dc.publisher	American Journal of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Urine 1H-NMR	en_US
dc.subject	Metabolomics	en_US
dc.subject	Neurocysticercosis	en_US
dc.subject	Exploratory Study	en_US
dc.title	Urine H-1-NMR Metabolomics to Discriminate Neurocysticercosis Patients from Healthy Controls: An Exploratory Study	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.22-0045
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645