Universidad Peruana Cayetano Heredia

Experimental brain infection with cysticercosis in sheep

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dc.contributor.author Sota Ortecho, K. A.
dc.contributor.author Bustos Palomino, Javier Arturo
dc.contributor.author Verastegui Pimentel, Manuela Renee
dc.contributor.author Toribio, Luz
dc.contributor.author Chile Andrade, Nancy
dc.contributor.author Angulo, Noelia
dc.contributor.author Cangalaya, Carla
dc.contributor.author Calcina, J.
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2022-12-14T14:25:35Z
dc.date.available 2022-12-14T14:25:35Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12906
dc.description.abstract Objective. To explore the feasibility of developing a sheep model of neurocysticercosis (NCC) by intracranial infection with T. solium oncospheres. Materials and methods. We carried out an experimental infection model of NCC in sheep. Approximately 10 T. solium oncospheres previously cultured for 30 days were inoculated intracranially into ten sheep. The oncospheres, in 0.1 mL of physiological saline, were injected into the parietal lobe through an 18-gauge needle. Results. After three months, granulo-mas were found in two sheep. In a third sheep we identified a 5 mm diameter cyst in the right lateral ventricle and histological evaluation confirmed that the cyst corresponded to a T. solium larva. Immuno-histochemistry with monoclonal antibodies directed against membrane components and excretory/se-cretory antigens of the T. solium cyst was also used to confirm the etiology of the found granulomas. One of them showed reactivity to the monoclonal antibodies used, thus confirming that it was a cysticercus. Conclusion. This experiment is the proof of concept that it is possible to infect sheep with cysticercosis by intracranial inoculation. en_US
dc.language.iso eng
dc.publisher Instituto Nacional de Salud
dc.relation.ispartofseries Revista Peruana de Medicina Experimental y Salud Publica
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Neurocysticercosis en_US
dc.subject Epilepsy en_US
dc.subject Cysticercosis source: MeSH NLM) en_US
dc.subject Sheep, Taenia solium en_US
dc.title Experimental brain infection with cysticercosis in sheep en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.17843/rpmesp.2022.393.11039
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1726-4642


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