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Impact of international travel and diarrhea on gut microbiome and resistome dynamics

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dc.contributor.author Boolchandani, Manish
dc.contributor.author Blake, Kevin S.
dc.contributor.author Tilley, Drake H.
dc.contributor.author Cabada, Miguel M.
dc.contributor.author Schwartz, Drew J.
dc.contributor.author Patel, Sanket
dc.contributor.author Morales Fernández, María Luisa
dc.contributor.author Meza, Rina
dc.contributor.author Soto, Giselle
dc.contributor.author Isidean, Sandra D.
dc.contributor.author Porter, Chad K.
dc.contributor.author Simons, Mark P.
dc.contributor.author Dantas, Gautam
dc.date.accessioned 2023-01-06T13:40:12Z
dc.date.available 2023-01-06T13:40:12Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12998
dc.description.abstract International travel contributes to the global spread of antimicrobial resistance. Travelers’ diarrhea exacerbates the risk of acquiring multidrug-resistant organisms and can lead to persistent gastrointestinal disturbance post-travel. However, little is known about the impact of diarrhea on travelers’ gut microbiomes, and the dynamics of these changes throughout travel. Here, we assembled a cohort of 159 international students visiting the Andean city of Cusco, Peru and applied next-generation sequencing techniques to 718 longitudinally-collected stool samples. We find that gut microbiome composition changed significantly throughout travel, but taxonomic diversity remained stable. However, diarrhea disrupted this stability and resulted in an increased abundance of antimicrobial resistance genes that can remain high for weeks. We also identified taxa differentially abundant between diarrheal and non-diarrheal samples, which were used to develop a classification model that distinguishes between these disease states. Additionally, we sequenced the genomes of 212 diarrheagenic Escherichia coli isolates and found those from travelers who experienced diarrhea encoded more antimicrobial resistance genes than those who did not. In this work, we find the gut microbiomes of international travelers’ are resilient to dysbiosis; however, they are also susceptible to colonization by multidrug-resistant bacteria, a risk that is more pronounced in travelers with diarrhea. en_US
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartofseries Nature Communications
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Antimicrobial resistance en_US
dc.subject Microbiome en_US
dc.title Impact of international travel and diarrhea on gut microbiome and resistome dynamics en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/s41467-022-34862-w
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.00
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.03.00
dc.relation.issn 2041-1723


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