Universidad Peruana Cayetano Heredia

Preserved peak exercise capacity in Andean highlanders with excessive erythrocytosis both before and after isovolumic hemodilution.

Mostrar el registro sencillo del ítem

dc.contributor.author Anza Ramírez, Cecilia Isabel
dc.contributor.author Gu, Wanjun
dc.contributor.author Macarlupú Bernuy, Jose Luis
dc.contributor.author Figueroa Mujiica, Romulo Joseph
dc.contributor.author Vizcardo Galindo, Gustavo Andrés
dc.contributor.author Heinrich, Erica C
dc.contributor.author Tift, Michael S
dc.contributor.author Wagner, Harrieth E
dc.contributor.author Wagner, Peter D
dc.contributor.author Simonson, Tatum S
dc.contributor.author Villafuerte Castrillón, Francisco Carlos
dc.coverage.spatial Cerro de Pasco, Pasco, Perú
dc.date.accessioned 2023-02-20T13:28:09Z
dc.date.available 2023-02-20T13:28:09Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13120
dc.description.abstract In chronic mountain sickness (CMS), increased blood oxygen (O2)-carrying capacity due to excessive erythrocytosis (EE, [Hb] ≥ 21 g/dL) could be offset, especially during exercise by both impaired cardiac output (Qt) and O2 diffusion limitation in lungs and muscle. We hypothesized that EE results in reduced peak Vo2 despite increased blood O2-carrying capacity, and that isovolumic hemodilution (IVHD) improves exercise capacity. In 14 male residents of Cerro de Pasco, Peru (4,340 m), six with and eight without EE, we measured peak cycle-exercise capacity, Vo2, Qt, arterial blood gas parameters, and (resting) blood volume. This was repeated for participants with EE after IVHD, reducing hematocrit by 20% (from 67% to 53%). From these data, we quantified the major O2 transport pathway components (ventilation, pulmonary alveolar-capillary diffusion, Qt, and blood-muscle mitochondria diffusion). Participants with EE had similar peak Vo2, systemic O2 delivery, and O2 extraction as non-EE controls, however, with lower Qt and higher arterial [O2]. After IVHD, peak Vo2 was preserved (but not enhanced), with lower O2 delivery (despite higher Qt) balanced by greater O2 extraction. The considerable variance in exercise capacity across the 14 individuals was explained essentially completely by differences in both pulmonary and muscle O2 diffusional conductances and not by any differences in ventilation, [Hb], nor Qt. In conclusion, EE does not result in lower peak Vo2 in Andean males, and IVHD maintains, but does not enhance, exercise capacity.NEW & NOTEWORTHY Male Andean highlanders with and without excessive erythrocytosis (EE) have similar peak Vo2 at 4,340 m, with higher arterial [O2] in EE and lower cardiac output (Qt), thus maintaining similar O2 delivery. Peak Vo2 in participants with EE was unaffected by isovolumic hemodilution (hematocrit reduced from 67% to 53%), with lower O2 delivery balanced by slightly increased Qt and greater O2 extraction. Differences in lung and muscle diffusing capacity, and not hematocrit variation, accounted for essentially all interindividual variance in peak Vo2. en_US
dc.language.iso eng
dc.publisher American Physiological Society
dc.relation.ispartofseries Journal of Applied Physiology (1985)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Andean highlanders en_US
dc.subject chronic mountain sickness en_US
dc.subject exercise capacity en_US
dc.subject excessive erythrocytosis en_US
dc.subject isovolumic hemodilution en_US
dc.subject.mesh Andean Ecosystem
dc.subject.mesh Altitude Sickness
dc.subject.mesh Exercise
dc.subject.mesh Polycythemia
dc.subject.mesh Hemodilution
dc.title Preserved peak exercise capacity in Andean highlanders with excessive erythrocytosis both before and after isovolumic hemodilution. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1152/japplphysiol.00439.2022
dc.relation.issn 1522-1601


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas