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Detection of Monkeypox Virus according to The Collection Site of Samples from Confirmed Cases: A Systematic Review

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dc.contributor.author León Figueroa, Darwin Anthony
dc.contributor.author Barboza, Joshuan J.
dc.contributor.author Saldaña Cumpa, Hortencia Milagros
dc.contributor.author Moreno-Ramos, Emilly
dc.contributor.author Bonilla-Aldana, Katterine
dc.contributor.author Valladares Garrido, Mario J.
dc.contributor.author Rodriguez Morales, Alfonso J.
dc.date.accessioned 2023-02-20T13:28:10Z
dc.date.available 2023-02-20T13:28:10Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13151
dc.description.abstract Due to the rapid evolution of the monkeypox virus, the means by which the monkeypox virus is spread is subject to change. Therefore, the present study aims to analyze the detection of the monkeypox virus according to the collection site of samples from confirmed monkeypox cases. A systematic literature review was performed using PubMed, Scopus, Web of Science, and Embase databases until 5 October 2022. A total of 1022 articles were retrieved using the search strategy. After removing duplicates (n = 566) and examining by title, abstract, and full text, 65 studies reporting monkeypox case reports were included with a detailed description of risk factors, sexually transmitted infections (STIs), site of monkeypox virus-positive specimens, location of skin lesions, and diagnostic test. A total of 4537 confirmed monkeypox cases have been reported, of which 98.72% of the cases were male with a mean age of 36 years, 95.72% had a sexual behavior of being men who have sex with men, and 28.1% had human immunodeficiency virus (HIV). The most frequent locations of lesions in patients diagnosed with monkeypox were: 42.85% on the genitalia and 37.1% in the perianal region. All confirmed monkeypox cases were diagnosed by reverse transcriptase polymerase chain reaction (RT-PCR), and the most frequent locations of samples collected for diagnosis that tested positive for monkeypox virus were: 91.85% from skin lesions, 20.81% from the oropharynx, 3.19% from blood, and 2.43% from seminal fluid. The disease course of the cases with monkeypox was asynchronous, with no severe complications, and most patients did not report specific treatment but simply followed a symptomatic treatment. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Tropical Medicine and Infectious Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject monkeypox en_US
dc.subject samples en_US
dc.subject orthopoxvirus en_US
dc.subject monkeypox virus en_US
dc.subject systematic review en_US
dc.subject.mesh Monkeypox
dc.subject.mesh Sampling Studies
dc.subject.mesh Orthopoxvirus
dc.subject.mesh Monkeypox virus
dc.subject.mesh Systematic Review
dc.title Detection of Monkeypox Virus according to The Collection Site of Samples from Confirmed Cases: A Systematic Review en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.3390/tropicalmed8010004
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 2414-6366


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