Universidad Peruana Cayetano Heredia

Biological Markers to Predict Outcome in Mechanically Ventilated Patients with Severe COVID-19 Living at High Altitude

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dc.contributor.author Vélez Páez, Jorge Luis
dc.contributor.author Pelosi, Paolo
dc.contributor.author Battaglini, Denise
dc.contributor.author Best, Ivan
dc.coverage.spatial Hospital Provincial General Pablo Arturo Suárez, Quito, Ecuador
dc.date.accessioned 2023-02-20T13:28:11Z
dc.date.available 2023-02-20T13:28:11Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13156
dc.description.abstract BACKGROUND: There is not much evidence on the prognostic utility of different biological markers in patients with severe COVID-19 living at high altitude. The objective of this study was to determine the predictive value of inflammatory and hematological markers for the risk of mortality at 28 days in patients with severe COVID-19 under invasive mechanical ventilation, living at high altitude and in a low-resource setting.METHODS: We performed a retrospective observational study including patients with severe COVID-19, under mechanical ventilation and admitted to the intensive care unit (ICU) located at 2850 m above sea level, between 1 April 2020 and 1 August 2021. Inflammatory (interleukin-6 (IL-6), ferritin, D-dimer, lactate dehydrogenase (LDH)) and hematologic (mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), MPV/platelet ratio) markers were evaluated at 24 h and in subsequent controls, and when available at 48 h and 72 h after admission to the ICU. The primary outcome was the association of inflammatory and hematological markers with the risk of mortality at 28 days.RESULTS: We analyzed 223 patients (median age (1st quartile [Q1]-3rd quartile [Q3]) 51 (26-75) years and 70.4% male). Patients with severe COVID-19 and with IL-6 values at 24 h ≥ 11, NLR values at 24 h ≥ 22, and NLR values at 72 h ≥ 14 were 8.3, 3.8, and 3.8 times more likely to die at 28 days, respectively. The SOFA and APACHE-II scores were not able to independently predict mortality.CONCLUSIONS: In mechanically ventilated patients with severe COVID-19 and living at high altitude, low-cost and immediately available blood markers such as IL-6 and NLR may predict the severity of the disease in low-resource settings. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Journal of Clinical Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject SARS-CoV-2 en_US
dc.subject coronavirus infection en_US
dc.subject mortality en_US
dc.subject biomarkers en_US
dc.subject COVID-19 en_US
dc.subject.mesh SARS-CoV-2
dc.subject.mesh Coronavirus Infections
dc.subject.mesh Mortality
dc.subject.mesh Biomarkers
dc.subject.mesh COVID-19
dc.title Biological Markers to Predict Outcome in Mechanically Ventilated Patients with Severe COVID-19 Living at High Altitude en_US
dc.title.alternative Marcadores biológicos para predecir el resultado en pacientes con ventilación mecánica y COVID-19 grave que viven a gran altitud en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/jcm12020644
dc.relation.issn 2077-0383


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