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Antibiotic overuse in premature low-birth-weight infants in a developing country

Rueda, M.S.; Calderon-Anyosa, R.; Gonzales, J.; Turin, C.G.; Zea-Vera, A.; Zegarra, J.; Bellomo, S.; Cam, L.; Castaneda, A.; Ochoa Woodell, Theresa Jean (Wolters Kluwer Health, 2019)

Background: Neonatal sepsis is a leading cause of child morbidity and mortality, especially in premature and low birth weight infants. Prompt antibiotic therapy is warranted, but its inappropriate use leads to bacterial ...
The ARMADILLO text message intervention to improve the sexual and reproductive health knowledge of adolescents in Peru: Results of a randomized controlled trial

Perez-Lu, Jose E.; Guerrero, Fiorella; Cárcamo Cavagnaro, César Paul Eugenio; Alburqueque, Monica; Chiappe Gutierrez, Marina Angelica; Hindin, Michelle J.; Habib, Ndema; Say, Lale; Gonsalves, Lianne; Bayer, Angela M. (Public Library of Science, 2022)

Background The ARMADILLO Study determined whether adolescents able to access SRH information on-demand via SMS were better able to reject contraception-related myths and misconceptions as compared with adolescents receiving ...
Aspirin in patients undergoing noncardiac surgery

Devereaux, P.J.; Mrkobrada, M.; Sessler, D.I.; Leslie, K.; Alonso-Coello, P.; Kurz, A.; Villar, J.C.; Sigamani, A.; Biccard, B.M.; Meyhoff, C.S.; Parlow, J.L.; Guyatt, G.; Robinson, A.; Garg, A.X.; Rodseth, R.N.; Botto, F.; Lurati Buse, G.; Xavier, D.; Chan, M.T.V.; Tiboni, M.; Cook, D.; Kumar, P.A.; Forget, P.; Málaga Rodríguez, Germán Javier; Fleischmann, E.; Amir, M.; Eikelboom, J.; Mizera, R.; Torres, D.; Wang, C.Y.; VanHelder, T.; Paniagua, P.; Berwanger, O.; Srinathan, S.; Graham, M.; Pasin, L.; Le Manach, Y.; Gao, P.; Pogue, J.; Whitlock, R.; Lamy, A.; Kearon, C.; Baigent, C.; Chow, C.; Pettit, S.; Chrolavicius, S.; Yusuf, S. (Massachusetts Medical Society, 2014)

BACKGROUND: There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. ...
Clonidine in patients undergoing noncardiac surgery

Devereaux, P.J.; Sessler, D.I.; Leslie, K.; Kurz, A.; Mrkobrada, M.; Alonso-Coello, P.; Villar, J.C.; Sigamani, A.; Biccard, B.M.; Meyhoff, C.S.; Parlow, J.L.; Guyatt, G.; Robinson, A.; Garg, A.X.; Rodseth, R.N.; Botto, F.; Lurati Buse, G.; Xavier, D.; Chan, M.T.V.; Tiboni, M.; Cook, D.; Kumar, P.A.; Forget, P.; Málaga Rodríguez, Germán Javier; Fleischmann, E.; Amir, M.; Eikelboom, J.; Mizera, R.; Torres, D.; Wang, C.Y.; VanHelder, T.; Paniagua, P.; Berwanger, O.; Srinathan, S.; Graham, M.; Pasin, L.; Le Manach, Y.; Gao, P.; Pogue, J.; Whitlock, R.; Lamy, A.; Kearon, C.; Chow, C.; Pettit, S.; Chrolavicius, S.; Yusuf, S. (Massachusetts Medical Society, 2014)

BACKGROUND: Marked activation of the sympathetic nervous system occurs during and after non-cardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and ...
Combined predictors of neurodevelopment in very low birth weight preterm infants

Medina-Alva, Pilar; Duque, Kevin R.; Zea-Vera, Alonso; Bellomo, Sicilia; Cárcamo Cavagnaro, César Paul Eugenio; Guillén Pinto, Daniel; Rivas, Maria; Tori, Alfredo; Zegarra, Jaime; Cam, Luis; Castañeda, Anne; Villavicencio, Aasith; Ochoa Woodell, Theresa Jean (Elsevier, 2019)

Objective: To evaluate the combined prognostic value of neurological examination, head circumference and cranial ultrasound for neurodevelopmental delay (NDD) in very low birth weight (VLBW, <1500 g) preterm infants. ...
Effect of augmented reality books in salivary cortisol levels in hospitalized pediatric patients: A randomized cross-over trial

Alarcón Yaquetto, Dulce Esperanza; Tincopa, Jean P.; Guillén Pinto, Daniel; Bailon, Nataly; Cárcamo Cavagnaro, César Paul Eugenio (Elsevier, 2021)

OBJECTIVE: This study sought to assess the effect of reading augmented reality (AR) books on salivary cortisol levels in hospitalized pediatric patients compared to reading a standard children's book. METHODS: This was a ...
Effect of bovine lactoferrin on prevention of late-onset sepsis in infants <1500 g: a pooled analysis of individual patient data from two randomized controlled trials

Ochoa Woodell, Theresa Jean; Loli, Sebastián; Mendoza, Karina; Cárcamo Cavagnaro, César Paul Eugenio; Bellomo, Sicilia; Cam, Luis; Castañeda, Anne; Campos, Miguel; Jacobs, Jan; Cossey, Veerle; Zegarra, Jaime (NRC Research Press, 2020)

We previously conducted two randomized controlled trials with bovine lactoferrin (bLF) for the prevention of lateonset sepsis (LOS) in infants with a birth weight <2500 g (Study 1) and <2000 g (Study 2). The aim of this ...
The HOPE social media intervention for global HIV prevention in Peru: A cluster randomised controlled trial

Young, S.D.; Cumberland, W.G.; Nianogo, R.; Menacho Alvirio, Luis Alberto; Galea, J.T.; Coates, T. (Elsevier, 2015)

Background: Social media technologies offer new approaches to HIV prevention and promotion of testing. We examined the effi cacy of the Harnessing Online Peer Education (HOPE) social media intervention to increase HIV ...
In peru, reporting male sex partners imparts significant risk of incident HIV/sexually transmitted infection: All men engaging in same-sex behavior need prevention services

Konda, Kelika A.; Lescano Guevara, Andres Guillermo; Celentano, David D.; Hall, Eric; Montano, Silvia M.; Kochel, Tadeusz J.; Coates, ThomasJ.; Caceres Palacios, Carlos Fernando (Wolters Kluwer Health, 2013)

Background: Detailed information on the sexual behavior of bisexual, non–gay-identified men and the relationship between same-sex behavior and HIV/sexually transmitted infection (STI) incidence is limited. This study ...
Long-Term Efficacy and Safety of Biosimilar CT-P10 Versus Innovator Rituximab in Rheumatoid Arthritis: 48-Week Results from a Randomized Phase III Trial

Suh, Chang-Hee; Yoo, Dae Hyun; Berrocal Kasay, Alfredo; Chalouhi El-Khouri, Elia; Cons Molina, Francisco Fidenci; Shesternya, Pavel; Miranda, Pedro; Medina-Rodriguez, Francisco G.; Wiland, Piotr; Jeka, Slawomir; Chavez-Corrales, Jose; Linde, Thomas; Hrycaj, Pawel; Abello-Banfi, Mauricio; Hospodarskyy, Ihor; Jaworski, Janusz; Piotrowski, Mariusz; Brzosko, Marek; Krogulec, Marek; Shevchuk, Sergii; Calvo, Armando; Andersone, Daina; Park, Won; Shim, Seung Cheol; Lee, Sang Joon; Lee, Sung Young (Springer, 2019)

Objective: The aim of this study was to investigate long-term clinical outcomes of extended treatment with CT-P10, a rituximab biosimilar, compared with rituximab reference products sourced from the USA and the EU (US-RTX ...
Longitudinal assessment of high versus low levels of fractional exhaled nitric oxide among children with asthma and atopy

Elmasri, Mary; Romero Rivero, Karina Maribel; Gilman, Robert Hugh; Hansel, Nadia N.; Robinson, Colin L.; Baumann, Lauren M.; Cabrera, Lilia; Hamilton, Robert G.; Checkley, William; Combe, Juan; Gomez, Alfonso; Gonzalvez, Guillermo; Barnes, Kathleen; Wise, Robert; Breysse, Patrick; Williams, D'Ann (Springer, 2014)

Purpose: Fractional exhaled nitric oxide (FeNO) has emerged as an important biomarker in asthma. Increasing evidence points to atopy as a confounding factor in the interpretation of elevated FeNO. We conducted a longitudinal ...
Multidrug-resistant tuberculosis and culture conversion with bedaquiline

Diacon, Andreas H.; Pym, Alexander; Grobusch, Martin P.; De Los Rios, Jorge M.; Gotuzzo Herencia, José Eduardo; Vasilyeva, Irina; Leimane, Vaira; Andries, Koen; Bakare, Nyasha; De Marez, Tine; Haxaire-Theeuwes, Myriam; Lounis, Nacer; Meyvisch, Paul; De Paepe, Els; Van Heeswijk, Rolf P.G.; Dannemann, Brian (Massachusetts Medical Society, 2014)

BACKGROUND: Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when ...
The Peru urban versus rural asthma (PURA) study: Methods and baseline quality control data from a cross-sectional investigation into the prevalence, severity, genetics, immunology and environmental factors affecting asthma in adolescence in Peru

Robinson, C.L.; Baumann, L.M.; Gilman, Robert Hugh; Romero Rivero, Karina Maribel; Combe, J.M.; Cabrera, L.; Hansel, N.N.; Barnes, K.; Gonzalvez, G.; Wise, R.A.; Breysse, P.N.; Checkley, W. (BMJ Publishing Group, 2012)

Objectives: According to a large-scale international survey, Peru has one of the highest prevalences of asthma worldwide; however, data from this survey were limited to participants from urban Lima.s sought to characterise ...
Pharmacokinetics and absorption of paromomycin and gentamicin from topical creams used to treat cutaneous leishmaniasis

Ravis, William R.; Llanos Cuentas, Elmer Alejandro; Sosa, Nestor; Kreishman-Deitrick, Mara; Kopydlowski, Karen M.; Nielsen, Carl; Smith, Kristen S.; Smith, Philip L.; Ransom, Janet H.; Lin, Yuh-Jing; Grogl, Max (American Society for Microbiology, 2013)

This study evaluated the pharmacokinetics of topical creams containing 15% paromomycin (“paromomycin alone”) and 15% paromomycin plus 0.5% gentamicin (WR 279,396) in patients with cutaneous leishmaniasis. The investigational ...
Pharmacokinetics, safety, and tolerability of oxfendazole in healthy volunteers: A randomized, placebo-controlled first-inhuman single-dose escalation study

An, G.; Murry, D.J.; Gajurel, K.; Bach, T.; Deye, G.; Stebounova, L.V.; Codd, E.E.; Horton, J.; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo; Ince, D.; Hodgson-Zingman, D.; Nomicos, E.Y.H.; Conrad, T.; Kennedy, J.; Jones, W.; Gilman, Robert Hugh; Winokur, P. (American Society for Microbiology, 2019)

Cysticercosis is a parasitic disease that frequently involves the human central nervous system (CNS), and current treatment options are limited. Oxfendazole, a veterinary medicine belonging to the benzimidazole family of ...
Randomized trial of early bubble continuous positive airway pressure for very low birth weight infants

Tapia, J.L.; Urzua, S.; Bancalari, A.; Meritano, J.; Torres, G.; Fabres, J.; Toro, C.A.; Rivera, F.; Cespedes, E.; Burgos, J.F.; Mariani, G.; Roldan, L.; Silvera, F.; Gonzalez, Agustina; Dominguez, A. (Elsevier, 2012)

Objective: To determine whether very low birth weight infants (VLBWIs), initially supported with continuous positive airway pressure (CPAP) and then selectively treated with the INSURE (intubation, surfactant, and extubation ...
Randomized trial of HPV4 vaccine assessing the response to HPV4 vaccine in two schedules among Peruvian female sex workers

Brown, B.; Blas Blas, Magaly Marlitz; Cabral, A.; Cárcamo Cavagnaro, César Paul Eugenio; Gravitt, P.; Halsey, N. (Elsevier, 2012)

Two hundred female sex workers (FSWs) in Lima, Peru were randomized to receive HPV4 vaccine in the standard (0, 2, 6 months) or a modified schedule (0, 3, 6 months). One hundred and eighty four (92%) participants completed ...
Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results

Pan, Hongchao; Peto, Richard; Henao-Restrepo, Ana-Maria; Preziosi, Marie-Pierre; Sathiyamoorthy, Vasee; Abdool Karim, Quarraisha; Alejandria, Marissa M.; Hernández García, César; Kieny, Marie-Paule; Malekzadeh, Reza; Murthy, Srinivas; Reddy, K. Srinath; Roses Periago, Mirta; Abi Hanna, Pierre; Ader, Florence; Al-Bader, Abdullah M.; Alhasawi, Almonther; Allum, Emma; Alotaibi, Athari; Alvarez-Moreno, Carlos A.; Appadoo, Sheila; Asiri, Abdullah; Aukrust, Pål; Barratt-Due, Andreas; Bellani, Samir; Branca, Mattia; Cappel-Porter, Heike B. C.; Cerrato, Nery; Chow, Ting S.; Como, Najada; Eustace, Joe; Garcia Funegra, Patricia Jannet; Godbole, Sheela; Gotuzzo Herencia, José Eduardo; Griskevicius, Laimonas; Hamra, Rasha; Hassan, Mariam; Hassany, Mohamed; Hutton, David; Irmansyah, Irmansyah; Jancoriene, Ligita; Kirwan, Jana; Kumar, Suresh; Lennon, Peter; Lopardo, Gustavo; Lydon, Patrick; Magrini, Nicola; Maguire, Teresa; Manevska, Suzana; Manuel, Oriol; McGinty, Sibylle; Medina, Marco T.; Mesa Rubio, María L.; Miranda-Montoya, Maria C.; Nel, Jeremy; Nunes, Estevao P.; Perola, Markus; Portolés, Antonio; Rasmin, Menaldi R.; Raza, Aun; Rees, Helen; Reges, Paula P. S.; Rogers, Chris A.; Salami, Kolawole; Salvadori, Marina I.; Sinani, Narvina; Sterne, Jonathan A. C.; Stevanovikj, Milena; Tacconelli, Evelina; Tikkinen, Kari A. O.; Trelle, Sven; Zaid, Hala; Røttingen, John-Arne; Swaminathan, Soumya (Massachusetts Medical Society, 2020)

BACKGROUND: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with ...
Response to: 'Clinical evidence guidelines in systemic lupus erythematosus: revaluation' by Scheinberg.

Pons-Estel, Bernardo A.; Bonfa, Eloisa; Soriano, Enrique R.; Cardiel, Mario Humberto; Izcovich, Ariel; Vázquez, Gloria; Alarcón, Graciela S. (BMJ Publishing Group, 2018)

We want to thank Dr Morton Scheinberg for his interest1 in our recent lupus guidelines communication.2 In his letter, he points out several concerns regarding belimumab which we had recommended at the same therapeutic level ...
Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non-cardiac surgery

Conen, David; Alonso-Coello, Pablo; Douketis, James; Chan, Matthew T. V.; Kurz, Andrea; Sigamani, Alben; Parlow, Joel L.; Wang, Chew Yin; Villar, Juan C.; Srinathan, Sadeesh K.; Tiboni, Maria; Málaga Rodríguez, Germán Javier; Guyatt, Gordon; Sivakumaran, Soori; Rodriguez Funes, Maria-Virginia; Cruz, Patricia; Yang, Homer; Dresser, George K.; Alvarez-Garcia, Jesus; Schricker, Thomas; Jones, Philip M.; Drummond, Leanne W.; Balasubramanian, Kumar; Yusuf, Salim; Devereaux, P. J. (Oxford University Press, 2019)

AIMS: To determine the 1-year risk of stroke and other adverse outcomes in patients with a new diagnosis of perioperative atrial fibrillation (POAF) after non-cardiac surgery. METHODS AND RESULTS: The PeriOperative ISchemic ...