A Rapid Point-of-Care Assay for Cysticercosis Antigen Detection in Urine Samples

O'Neal, Seth E.; García Lescano, Héctor Hugo; Bustos Palomino, Javier Arturo; Handali, Sukwan; Toribio Salazar, Luz Milagros; Perez, Erika; Castillo Berrios, Yesenia; Marin, Yazmin

dc.contributor.author	Toribio Salazar, Luz Milagros
dc.contributor.author	Handali, Sukwan
dc.contributor.author	Marin, Yazmin
dc.contributor.author	Perez, Erika
dc.contributor.author	Castillo Berrios, Yesenia
dc.contributor.author	Bustos Palomino, Javier Arturo
dc.contributor.author	O'Neal, Seth E.
dc.contributor.author	García Lescano, Héctor Hugo
dc.date.accessioned	2023-04-16T04:38:11Z
dc.date.available	2023-04-16T04:38:11Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/20.500.12866/13350
dc.description.abstract	We report a proof-of-concept study using a dipstick assay to detect Taenia solium antigen in urine samples of 30 patients with subarachnoid neurocysticercosis and 10 healthy control subjects. Strips were read in blind by two readers. The assay detected antigen in 29 of 30 cases and was negative in all 10 control samples. Although this study was performed in samples from individuals with subarachnoid neurocysticercosis who likely had high circulating antigen levels, it provides the proof of concept for a functional urine antigen point-of-care assay that detects viable cysts. Such an assay could serve to support a clinical diagnosis of suspect neurocysticercosis or to identify patients at risk of developing severe disease in areas where medical resources are limited, providing evidence to refer these individuals for imaging and specialized care as needed. Copyright © 2023 The American Society of Tropical Medicine and Hygiene.	en_US
dc.language.iso	eng
dc.publisher	American Journal of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Point-of-Care Assay	en_US
dc.subject	Cysticercosis Antigen Detection	en_US
dc.subject	Urine Samples	en_US
dc.title	A Rapid Point-of-Care Assay for Cysticercosis Antigen Detection in Urine Samples	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.22-0598
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645