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Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania.

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dc.contributor.author Zwyer, Michaela
dc.contributor.author Rutaihwa, Liliana K.
dc.contributor.author Windels, Etthel
dc.contributor.author Hella, Jerry
dc.contributor.author Menardo, Fabrizio
dc.contributor.author Sasamalo, Mohamed
dc.contributor.author Sommer, Gregor
dc.contributor.author Schmülling, Lena
dc.contributor.author Borrell, Sonia
dc.contributor.author Reinhard, Miriam
dc.contributor.author Dötsch, Anna
dc.contributor.author Hiza, Hellen
dc.contributor.author Stritt, Christoph
dc.contributor.author Sikalengo, George
dc.contributor.author Fenner, Lukas
dc.contributor.author De Jong, Bouke C.
dc.contributor.author Kato-Maeda, Midori
dc.contributor.author Jugheli, Levan
dc.contributor.author Ernst, Joel D.
dc.contributor.author Niemann, Stefan
dc.contributor.author Jeljeli, Leila
dc.contributor.author Ballif, Marie
dc.contributor.author Egger, Matthias
dc.contributor.author Rakotosamimanana, Niaina
dc.contributor.author Yeboah-Manu, Dorothy
dc.contributor.author Asare, Prince
dc.contributor.author Malla, Bijaya
dc.contributor.author Dou, Horng Yunn
dc.contributor.author Zetola, Nicolas
dc.contributor.author Wilkinson, Robert J.
dc.contributor.author Cox, Helen
dc.contributor.author Carter, E. Jane
dc.contributor.author Gnokoro, Joachim
dc.contributor.author Yotebieng, Marcel
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Abimiku, Alash'le
dc.contributor.author Avihingsanon, Anchalee
dc.contributor.author Xu, Zhi Ming
dc.contributor.author Fellay, Jacques
dc.contributor.author Portevin, Damien
dc.contributor.author Reither, Klaus
dc.contributor.author Stadler, Tanja
dc.contributor.author Gagneux, Sebastien
dc.contributor.author Brites, Daniela
dc.coverage.spatial Dar es Salaam, Tanzania
dc.date.accessioned 2023-04-16T04:38:12Z
dc.date.available 2023-04-16T04:38:12Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13355
dc.description.abstract In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied the MTBC population in Dar es Salaam, Tanzania over a six-year period, using 1,082 unique patient-derived MTBC whole-genome sequences (WGS) and associated clinical data. We show that the TB epidemic in Dar es Salaam is dominated by multiple MTBC genotypes introduced to Tanzania from different parts of the world during the last 300 years. The most common MTBC genotypes deriving from these introductions exhibited differences in transmission rates and in the duration of the infectious period, but little differences in overall fitness, as measured by the effective reproductive number. Moreover, measures of disease severity and bacterial load indicated no differences in virulence between these genotypes during active TB. Instead, the combination of an early introduction and a high transmission rate accounted for the high prevalence of L3.1.1, the most dominant MTBC genotype in this setting. Yet, a longer co-existence with the host population did not always result in a higher transmission rate, suggesting that distinct life-history traits have evolved in the different MTBC genotypes. Taken together, our results point to bacterial factors as important determinants of the TB epidemic in Dar es Salaam. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Pathogens
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Genomics en_US
dc.subject Phylogeography en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Tanzania en_US
dc.subject Africa en_US
dc.subject Tuberculosis en_US
dc.subject Asia en_US
dc.subject Phylogenetic analysis en_US
dc.title Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.ppat.1010893
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn 1553-7374


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