DSpace Repository

Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations

Show simple item record

dc.contributor.author Kaplan, Hillard
dc.contributor.author Hooper, Paul L.
dc.contributor.author Gatz, Margaret
dc.contributor.author Mack, Wendy J.
dc.contributor.author Law, E. Meng
dc.contributor.author Chui, Helena C.
dc.contributor.author Sutherland, M. Linda
dc.contributor.author Sutherland, James D.
dc.contributor.author Rowan, Christopher J.
dc.contributor.author Wann, L. Samuel
dc.contributor.author Allam, Adel H.
dc.contributor.author Thompson, Randall C.
dc.contributor.author Michalik, David E.
dc.contributor.author Lombardi Almonacin, Guido Paolo
dc.contributor.author Miyamoto, Michael I.
dc.contributor.author Rodriguez, Daniel Eid
dc.contributor.author Adrian, Juan Copajira
dc.contributor.author Gutierrez, Raul Quispe
dc.contributor.author Beheim, Bret A.
dc.contributor.author Cummings, Daniel K.
dc.contributor.author Seabright, Edmond
dc.contributor.author Alami, Sarah
dc.contributor.author Garcia, Angela R.
dc.contributor.author Buetow, Kenneth
dc.contributor.author Thomas, Gregory S.
dc.contributor.author Finch, Caleb E.
dc.contributor.author Stieglitz, Jonathan
dc.contributor.author Trumble, Benjamin C.
dc.contributor.author Gurven, Michael D.
dc.contributor.author Irimia, Andrei
dc.coverage.spatial Beni, Bolivia
dc.date.accessioned 2023-04-16T04:38:12Z
dc.date.available 2023-04-16T04:38:12Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13357
dc.description.abstract Little is known about brain aging or dementia in nonindustrialized environments that are similar to how humans lived throughout evolutionary history. This paper examines brain volume (BV) in middle and old age among two indigenous South American populations, the Tsimane and Moseten, whose lifestyles and environments diverge from those in high-income nations. With a sample of 1,165 individuals aged 40 to 94, we analyze population differences in cross-sectional rates of decline in BV with age. We also assess the relationships of BV with energy biomarkers and arterial disease and compare them against findings in industrialized contexts. The analyses test three hypotheses derived from an evolutionary model of brain health, which we call the embarrassment of riches (EOR). The model hypothesizes that food energy was positively associated with late life BV in the physically active, food-limited past, but excess body mass and adiposity are now associated with reduced BV in industrialized societies in middle and older ages. We find that the relationship of BV with both non-HDL cholesterol and body mass index is curvilinear, positive from the lowest values to 1.4 to 1.6 SDs above the mean, and negative from that value to the highest values. The more acculturated Moseten exhibit a steeper decrease in BV with age than Tsimane, but still shallower than US and European populations. Lastly, aortic arteriosclerosis is associated with lower BV. Complemented by findings from the United States and Europe, our results are consistent with the EOR model, with implications for interventions to improve brain health. en_US
dc.language.iso eng
dc.publisher National Academy of Sciences
dc.relation.ispartofseries Proceedings of the National Academy of Sciences of the United States of America
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Brain volume en_US
dc.subject energy balance en_US
dc.subject cardiovascular health en_US
dc.subject South America en_US
dc.title Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1073/pnas.2205448120
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#4.02.00
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.13
dc.relation.issn 1091-6490


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics