Universidad Peruana Cayetano Heredia

Colonizing and Virulence Factors in Enterotoxigenic Escherichia coli from Peru.

Mostrar el registro sencillo del ítem

dc.contributor.author Rivera Albinagorta, Fulton Paul
dc.contributor.author Medina Prada, Anicia Magaly
dc.contributor.author Riveros Ramirez, Maribel Denise
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Pons, Maria J.
dc.contributor.author Ruiz, Joaquim
dc.coverage.spatial Perú
dc.date.accessioned 2023-04-16T04:38:12Z
dc.date.available 2023-04-16T04:38:12Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13360
dc.description.abstract Enterotoxigenic Escherichia coli (ETEC) ranks among the most relevant diarrheagenic pathogens. Efforts to design vaccines to fight ETEC have been focused on colonizing factors (CFs) and atypical virulence factors (AVF). An effective vaccine must account for differences in the regional prevalence of these CFs and AVFs to be truly effective in a given area. In the present study, the presence of 16 CFs and 9 AVFs, as well as the heat-stable (ST) variants (STh or STp), was established by polymerase chain reaction in 205 Peruvian ETEC isolates (120 from diarrhea cases and 85 from healthy controls). Ninety-nine (48.3%) isolates were heat-labile, 63 (30.7%) ST, and 43 (21.0%) presented both toxins. Of ST isolates, 59 (28.8%) possessed STh, 30 (14.6%) STp, five (2.4%) both STh and STp, and 12 (5.8%) were not amplified for any variant tested. The presence of CFs was associated with diarrhea (P < 0.0001). The presence of eatA as well as concomitant presence of CSI, CS3, and CS21 and of C5 and C6 was statistically related to diarrhea cases. The present results suggests that, if effective, a vaccine considering CS6, CS20, and CS21, together with EtpA, would provide protection against 64.4% of the isolates analyzed, whereas the addition of CS12 and EAST1 would lead to 83.9% coverage. Large studies are needed to establish both the ideal candidates to be considered to develop a vaccine effective in the area, and continuous surveillance is needed to detect displacement of circulating isolates that may compromise future vaccines. en_US
dc.language.iso eng
dc.publisher American Journal of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Colonizing en_US
dc.subject Virulence en_US
dc.subject Enterotoxigenic en_US
dc.subject Escherichia coli en_US
dc.subject Peru en_US
dc.title Colonizing and Virulence Factors in Enterotoxigenic Escherichia coli from Peru. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.22-0677
dc.relation.issn 1476-1645


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas