Universidad Peruana Cayetano Heredia

Evidence of natural selection and dominance of SARS-CoV-2 variant Lambda (C.37) over variants of concern in Cusco, Peru

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dc.contributor.author Quispe-Ricalde, Maria Antonieta
dc.contributor.author Castelán-Sánchez, Hugo G.
dc.contributor.author Meza-Rodríguez, Pablo M.
dc.contributor.author Dávila-Ramos, Sonia
dc.contributor.author Sierra, José Luis
dc.contributor.author Batista-Garcia, Ramón
dc.contributor.author Concha-Velasco, Fátima
dc.contributor.author Lucana, Sonia Flores
dc.contributor.author De Santa Cruz, José
dc.contributor.author Zea, Víctor
dc.contributor.author Galarza, Marco
dc.contributor.author Caceres-Rey, Omar
dc.contributor.author Tsukayama Cisneros, Pablo
dc.contributor.author Foronda, Pilar
dc.contributor.author Soto-Chambi, Brandon Jason
dc.contributor.author Abreu, Nestor
dc.coverage.spatial Cusco, Perú
dc.date.accessioned 2023-04-16T04:38:14Z
dc.date.available 2023-04-16T04:38:14Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13372
dc.description.abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage C.37 (Lambda) has spread rapidly in Peru and other Latin American countries. However, most studies in Peru have focused on Lima, the capital city, without knowing the dynamics of the spread of the variant in other departments. Cusco, Peru, is one of the most popular departments in the country for tourists, so the introduction of new variants of SARS-CoV-2 might occur despite closure of the borders. Therefore, in this work, we analyzed the variants circulating in Cusco. The aim of this work was to better understand the distribution of SARS-CoV-2 lineages circulating in Cusco and to characterize the genomes of these strains. To this end, 46 SARS-CoV-2 genomes from vaccinated and unvaccinated patients were sequenced in the first half of 2021. The genomes were analyzed using phylogenetic and natural selection methods. Phylogenetic trees from Cusco showed dominance of the Lambda lineage over the variants of concern (VOCs), and there was no clustering of variants by district. Natural selection analysis revealed mutations, mainly in the spike protein, at positions 75, 246, 247, 707, 769, and 1020. In addition, we found that unvaccinated patients accumulated more new mutations than did vaccinated patients, and these included the F101Y mutation in ORF7a, E419A in NSP3, a deletion in S (21,618-22,501), and a deletion in ORF3a (25,437-26,122). © 2023, The Author(s). en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Archives of Virology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject COVID-19 en_US
dc.subject epidemiology en_US
dc.subject genetics en_US
dc.subject Peru en_US
dc.subject SARS-CoV-2 en_US
dc.subject coronavirus spike glycoprotein en_US
dc.subject Mutation en_US
dc.subject Phylogeny en_US
dc.subject spike protein, SARS-CoV-2 en_US
dc.title Evidence of natural selection and dominance of SARS-CoV-2 variant Lambda (C.37) over variants of concern in Cusco, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s00705-022-05645-x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.02
dc.relation.issn 0304-8608


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