Universidad Peruana Cayetano Heredia

Exploration of the Production of Three Thiodiketopiperazines by an Endophytic Fungal Strain of Cophinforma mamane

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dc.contributor.author Pacheco Tapia, Romina Geraldine
dc.contributor.author Ortíz, Sergio
dc.contributor.author Jargeat, Patricia
dc.contributor.author Amasifuen, Carlos
dc.contributor.author Vansteelandt, Marieke
dc.contributor.author Haddad, Mohamed
dc.coverage.spatial Amazonía peruana
dc.date.accessioned 2023-04-16T04:38:14Z
dc.date.available 2023-04-16T04:38:14Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13373
dc.description.abstract Endophytic fungi possess a versatile metabolism which is related to their ability to live in diverse ecological niches. While culturing under laboratory conditions, their metabolism is mainly influenced by the culture media, time of incubation and other physicochemical factors. In this study, we focused on the production of 3 thiodiketopiperazines (TDKPs) botryosulfuranols A−C produced by an endophytic strain of Cophinforma mamane isolated from the leaves of Bixa orellana L collected in the Peruvian Amazon. We studied the time-course production of botryosulfuranols A−C during 28 days and evaluated the variations in the production of secondary metabolites, including the TDKPs, produced by C. mamane in response to different culture media, light versus dark conditions and different incubation times. We observed a short time-frame production of botryosulfuranol C while its production was significantly affected by the light conditions and nutrients of the culture media. Botryosulfuranols A and B showed a similar production pattern and a similar response to culturing conditions. Molecular networking allowed us to detect three compounds related to TDKPs that will be the focus of future experiments. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Chemistry and Biodiversity
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cophinforma mamane en_US
dc.subject diketopiperazines en_US
dc.subject endophytic fungi en_US
dc.subject metabolomics en_US
dc.subject OSMAC en_US
dc.title Exploration of the Production of Three Thiodiketopiperazines by an Endophytic Fungal Strain of Cophinforma mamane en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/cbdv.202201087
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.05
dc.relation.issn 1612-1872


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