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Extra-genital Neisseria gonorrhoeae infections with genetic mutations conferring ciprofloxacin resistance among men who have sex with men and transgender women in Lima, Peru

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dc.contributor.author Qquellon Palacios, Luz Jazmín
dc.contributor.author Vargas Rivera, Silver Keith
dc.contributor.author Eguiluz, Maria
dc.contributor.author Vasquez, Francesca
dc.contributor.author Durand Vara, David Percy
dc.contributor.author Allan-Blitz, Lao-Tzu
dc.contributor.author Konda, Kelika Anne
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Klausner, Jeffrey D
dc.coverage.spatial Lima, Perú
dc.date.accessioned 2023-04-16T04:38:14Z
dc.date.available 2023-04-16T04:38:14Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13374
dc.description.abstract Background: The increasing prevalence of drug-resistant Neisseria gonorrhoeae (NG) infections has caused great concern. Ciprofloxacin remains the empiric antimicrobial recommended to treat NG infections in Peru disregarding the susceptibility profile of circulating NG strains. We report the prevalence of individuals infected with NG strains presenting mutations in the gyrA gene that confers ciprofloxacin resistance. Methods: We conducted a descriptive study assessing extragenital swab samples collected from a cohort of men who have sex with men and transgender women in Lima, Peru. Anal and pharyngeal NG positive swabs for Aptima Combo 2 assay (Hologic Inc., USA) were used for DNA extraction. We performed TaqMan real time PCR assays to detect a point mutation at codon Ser91 of the gyrase A (gyrA) gene. Results: From 156 individuals who had at least one positive sample for NG reported by the Aptima assay, 80 individuals had at least one amplified DNA for the gyrA gene. We found that 67 of them (84.0%) were infected with a gyrA-mutated NG strain at the Ser91 codon. Conclusions: We report a high prevalence of gyrA mutation conferring ciprofloxacin resistance among individuals with extragenital NG infection. Empirical treatment of NG needs to be urgently updated in Peru in concordance with international guidelines. © The Author(s) 2023. en_US
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartofseries International Journal of STD and AIDS
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Neisseria gonorrhoeae en_US
dc.subject gyrA gene en_US
dc.subject mutations en_US
dc.subject antimicrobial resistance en_US
dc.subject Peru en_US
dc.title Extra-genital Neisseria gonorrhoeae infections with genetic mutations conferring ciprofloxacin resistance among men who have sex with men and transgender women in Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1177/09564624221147326
dc.relation.issn 1758-1052


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