Universidad Peruana Cayetano Heredia

Factors Associated with COVID-19 Death in a High-Altitude Peruvian Setting during the First 14 Months of the Pandemic: A Retrospective Multicenter Cohort Study in Hospitalized Patients

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dc.contributor.author Concha-Velasco, Fátima
dc.contributor.author Moncada-Arias, Ana G.
dc.contributor.author Antich Barrientos, María Khaterine
dc.contributor.author Delgado-Flores, Carolina J.
dc.contributor.author Ramírez-Escobar, Cesar
dc.contributor.author Ochoa-Linares, Marina
dc.contributor.author Velásquez-Cuentas, Lucio
dc.contributor.author Dueñas de la Cruz, Homero
dc.contributor.author Loyola Sosa, Steev Orlando
dc.coverage.spatial Hospital Regional del Cusco, Cusco, Perú
dc.coverage.spatial Hospital Nacional Adolfo Guevara Velasco, Cusco, Perú
dc.coverage.spatial Hospital Antonio Lorena, Cusco, Perú
dc.date.accessioned 2023-04-16T04:38:14Z
dc.date.available 2023-04-16T04:38:14Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13375
dc.description.abstract Risk factors for COVID-19 death in high-altitude populations have been scarcely described. This study aimed to describe risk factors for COVID-19 death in three referral hospitals located at 3399 m in Cusco, Peru, during the first 14 months of the pandemic. A retrospective multicenter cohort study was conducted. A random sample of ~50% (1225/2674) of adult hospitalized patients who died between 1 March 2020 and 30 June 2021 was identified. Of those, 977 individuals met the definition of death by COVID-19. Demographic characteristics, intensive care unit (ICU) admission, invasive respiratory support (IRS), disease severity, comorbidities, and clinical manifestation at hospital admission were assessed as risk factors using Cox proportional-hazard models. In multivariable models adjusted by age, sex, and pandemic periods, critical disease (vs. moderate) was associated with a greater risk of death (aHR: 1.27; 95%CI: 1.14–1.142), whereas ICU admission (aHR: 0.39; 95%CI: 0.27–0.56), IRS (aHR: 0.37; 95%CI: 0.26–0.54), the ratio of oxygen saturation (ROX) index ≥ 5.3 (aHR: 0.87; 95%CI: 0.80–0.94), and the ratio of SatO2/FiO2 ≥ 122.6 (aHR: 0.96; 95%CI: 0.93–0.98) were associated with a lower risk of death. The risk factors described here may be useful in assisting decision making and resource allocation. © 2023 by the authors. en_US
dc.language.iso eng
dc.publisher Multidisciplinary Digital Publishing Institute
dc.relation.ispartofseries Tropical Medicine and Infectious Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject COVID-19 en_US
dc.subject Peru en_US
dc.subject hospitalization en_US
dc.subject high altitude en_US
dc.subject Cusco en_US
dc.subject death en_US
dc.subject intensive care units en_US
dc.subject mechanical ventilator en_US
dc.subject risk factors en_US
dc.title Factors Associated with COVID-19 Death in a High-Altitude Peruvian Setting during the First 14 Months of the Pandemic: A Retrospective Multicenter Cohort Study in Hospitalized Patients en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/tropicalmed8030133
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 2414-6366


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