Universidad Peruana Cayetano Heredia

First Report of OXA-181-Producing Enterobacterales Isolates in Latin America

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dc.contributor.author Cuicapuza Arteaga, Diego Bernhard
dc.contributor.author Alvarado, Luis
dc.contributor.author Tocasca, Norah
dc.contributor.author Aguilar, Daniel
dc.contributor.author Gómez-de-la-Torre, Juan Carlos
dc.contributor.author Salvatierra Rodríguez, Guillermo Santos
dc.contributor.author Tsukayama Cisneros, Pablo
dc.contributor.author Tamariz Ortiz, Jesús Humberto
dc.coverage.spatial Lima, Perú
dc.date.accessioned 2023-04-16T04:38:14Z
dc.date.available 2023-04-16T04:38:14Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13376
dc.description.abstract We characterized five carbapenemase-producing <i>Enterobacterales</i> (CPE) isolates from two health care institutions in Lima, Peru. The isolates were identified as Klebsiella pneumoniae (<i>n</i> = 3), Citrobacter portucalensis (<i>n</i> = 1), and Escherichia coli (<i>n</i> = 1). All were identified as <i>bla</i><sub>OXA-48</sub>-like gene carriers using conventional PCR. Whole-genome sequencing found the presence of the <i>bla</i><sub>OXA-181</sub> gene as the only carbapenemase gene in all isolates. Genes associated with resistance to aminoglycosides, quinolones, amphenicols, fosfomycins, macrolides, tetracyclines, sulfonamides, and trimethoprim were also found. The plasmid incompatibility group IncX3 was identified in all genomes in a truncated Tn<i>6361</i> transposon flanked by ΔIS<i>26</i> insertion sequences. The <i>qnrS1</i> gene was also found downstream of <i>bla</i><sub>OXA-181</sub>, conferring fluoroquinolone resistance to all isolates. CPE isolates harboring <i>bla</i><sub>OXA</sub>-like genes are an increasing public health problem in health care settings worldwide. The IncX3 plasmid is involved in the worldwide dissemination of <i>bla</i><sub>OXA-181</sub>, and its presence in these CPE isolates suggests the wide dissemination of <i>bla</i><sub>OXA-181</sub> in Peru. <b>IMPORTANCE</b> Reports of carbapenemase-producing <i>Enterobacterales</i> (CPE) isolates are increasing worldwide. Accurate detection of the β-lactamase OXA-181 (a variant of OXA-48) is important to initiate therapy and preventive measures in the clinic. OXA-181 has been described in CPE isolates in many countries, often associated with nosocomial outbreaks. However, the circulation of this carbapenemase has yet to be reported in Peru. Here, we report the detection of five multidrug-resistant CPE clinical isolates harboring <i>bla</i><sub>OXA-181</sub> in the IncX3-type plasmid, a potential driver of dissemination in Peru. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartofseries Microbiology Spectrum
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject blaOXA-181 en_US
dc.subject carbapenemase-producing Enterobacterales en_US
dc.subject IncX3 plasmid en_US
dc.subject Peru en_US
dc.subject carbapenemase-producing Enterobacteriaceae en_US
dc.title First Report of OXA-181-Producing Enterobacterales Isolates in Latin America en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/spectrum.04584-22
dc.relation.issn 2165-0497


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