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Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

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dc.contributor.author Young, William J.
dc.contributor.author Haessler, Jeffrey
dc.contributor.author Benjamins, Jan-Walter
dc.contributor.author Repetto, Linda
dc.contributor.author Yao, Jie
dc.contributor.author Isaacs, Aaron
dc.contributor.author Harper, Andrew R.
dc.contributor.author Ramirez, Julia
dc.contributor.author Garnier, Sophie
dc.contributor.author van Duijvenboden, Stefan
dc.contributor.author Baldassari, Antoine R.
dc.contributor.author Concas, Maria Pina
dc.contributor.author Duong, ThuyVy
dc.contributor.author Foco, Luisa
dc.contributor.author Isaksen, Jonas L.
dc.contributor.author Mei, Hao
dc.contributor.author Noordam, Raymond
dc.contributor.author Nursyifa, Casia
dc.contributor.author Richmond, Anne
dc.contributor.author Santolalla Robles, Meddly Leslye
dc.contributor.author Sitlani, Colleen M.
dc.contributor.author Soroush, Negin
dc.contributor.author Thériault, Sébastien
dc.contributor.author Trompet, Stella
dc.contributor.author Aeschbacher, Stefanie
dc.contributor.author Ahmadizar, Fariba
dc.contributor.author Alonso, Alvaro
dc.contributor.author Brody, Jennifer A.
dc.contributor.author Campbell, Archie
dc.contributor.author Correa, Adolfo
dc.contributor.author Darbar, Dawood
dc.contributor.author De Luca, Antonio
dc.contributor.author Deleuze, Jean-François
dc.contributor.author Ellervik, Christina
dc.contributor.author Fuchsberger, Christian
dc.contributor.author Goel, Anuj
dc.contributor.author Grace, Christopher
dc.contributor.author Guo, Xiuqing
dc.contributor.author Hansen, Torben
dc.contributor.author Heckbert, Susan R.
dc.contributor.author Jackson, Rebecca D.
dc.contributor.author Kors, Jan A.
dc.contributor.author Lima-Costa, Maria Fernanda
dc.contributor.author Linneberg, Allan
dc.contributor.author Macfarlane, Peter W.
dc.contributor.author Morrison, Alanna C.
dc.contributor.author Navarro, Pau
dc.contributor.author Porteous, David J.
dc.contributor.author Pramstaller, Peter P.
dc.contributor.author Reiner, Alexander P.
dc.contributor.author Risch, Lorenz
dc.contributor.author Schotten, Ulrich
dc.contributor.author Shen, Xia
dc.contributor.author Sinagra, Gianfranco
dc.contributor.author Soliman, Elsayed Z.
dc.contributor.author Stoll, Monika
dc.contributor.author Tarazona-Santos, Eduardo
dc.contributor.author Tinker, Andrew
dc.contributor.author Trajanoska, Katerina
dc.contributor.author Villard, Eric
dc.contributor.author Warren, Helen R.
dc.contributor.author Whitsel, Eric A.
dc.contributor.author Wiggins, Kerri L.
dc.contributor.author Arking, Dan E.
dc.contributor.author Avery, Christy L.
dc.contributor.author Conen, David
dc.contributor.author Girotto, Giorgia
dc.contributor.author Grarup, Niels
dc.contributor.author Hayward, Caroline
dc.contributor.author Jukema, J.Wouter
dc.contributor.author Mook-Kanamori, Dennis O.
dc.contributor.author Olesen, Morten Salling
dc.contributor.author Padmanabhan, Sandosh
dc.contributor.author Psaty, Bruce M.
dc.contributor.author Pattaro, Cristian
dc.contributor.author Ribeiro, Antonio Luiz P.
dc.contributor.author Rotter, Jerome I.
dc.contributor.author Stricker, Bruno H.
dc.contributor.author van der Harst, Pim
dc.contributor.author van Duijn, Cornelia M.
dc.contributor.author Verweij, Niek
dc.contributor.author Wilson, James G.
dc.contributor.author Orini, Michele
dc.contributor.author Charron, Philippe
dc.contributor.author Watkins, Hugh
dc.contributor.author Kooperberg, Charles
dc.contributor.author Lin, Henry J.
dc.contributor.author Wilson, James F.
dc.contributor.author Kanters, Jørgen K.
dc.contributor.author Sotoodehnia, Nona
dc.contributor.author Mifsud, Borbala
dc.contributor.author Lambiase, Pier D.
dc.contributor.author Tereshchenko, Larisa G.
dc.contributor.author Munroe, Patricia B.
dc.date.accessioned 2023-04-16T04:38:14Z
dc.date.available 2023-04-16T04:38:14Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13379
dc.description.abstract The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction. © 2023, The Author(s). en_US
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartofseries Nature Communications
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Risk Factors en_US
dc.subject Biomarkers en_US
dc.subject *Atrioventricular Block en_US
dc.subject *Cardiovascular Diseases/genetics en_US
dc.subject Arrhythmias, Cardiac/genetics en_US
dc.subject Electrocardiography/methods en_US
dc.subject Genome-Wide Association Study en_US
dc.title Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/s41467-023-36997-w
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.00
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.03.00
dc.relation.issn 2041-1723


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