Universidad Peruana Cayetano Heredia
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
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| dc.contributor.author | Young, William J. | |
| dc.contributor.author | Haessler, Jeffrey | |
| dc.contributor.author | Benjamins, Jan-Walter | |
| dc.contributor.author | Repetto, Linda | |
| dc.contributor.author | Yao, Jie | |
| dc.contributor.author | Isaacs, Aaron | |
| dc.contributor.author | Harper, Andrew R. | |
| dc.contributor.author | Ramirez, Julia | |
| dc.contributor.author | Garnier, Sophie | |
| dc.contributor.author | van Duijvenboden, Stefan | |
| dc.contributor.author | Baldassari, Antoine R. | |
| dc.contributor.author | Concas, Maria Pina | |
| dc.contributor.author | Duong, ThuyVy | |
| dc.contributor.author | Foco, Luisa | |
| dc.contributor.author | Isaksen, Jonas L. | |
| dc.contributor.author | Mei, Hao | |
| dc.contributor.author | Noordam, Raymond | |
| dc.contributor.author | Nursyifa, Casia | |
| dc.contributor.author | Richmond, Anne | |
| dc.contributor.author | Santolalla Robles, Meddly Leslye | |
| dc.contributor.author | Sitlani, Colleen M. | |
| dc.contributor.author | Soroush, Negin | |
| dc.contributor.author | Thériault, Sébastien | |
| dc.contributor.author | Trompet, Stella | |
| dc.contributor.author | Aeschbacher, Stefanie | |
| dc.contributor.author | Ahmadizar, Fariba | |
| dc.contributor.author | Alonso, Alvaro | |
| dc.contributor.author | Brody, Jennifer A. | |
| dc.contributor.author | Campbell, Archie | |
| dc.contributor.author | Correa, Adolfo | |
| dc.contributor.author | Darbar, Dawood | |
| dc.contributor.author | De Luca, Antonio | |
| dc.contributor.author | Deleuze, Jean-François | |
| dc.contributor.author | Ellervik, Christina | |
| dc.contributor.author | Fuchsberger, Christian | |
| dc.contributor.author | Goel, Anuj | |
| dc.contributor.author | Grace, Christopher | |
| dc.contributor.author | Guo, Xiuqing | |
| dc.contributor.author | Hansen, Torben | |
| dc.contributor.author | Heckbert, Susan R. | |
| dc.contributor.author | Jackson, Rebecca D. | |
| dc.contributor.author | Kors, Jan A. | |
| dc.contributor.author | Lima-Costa, Maria Fernanda | |
| dc.contributor.author | Linneberg, Allan | |
| dc.contributor.author | Macfarlane, Peter W. | |
| dc.contributor.author | Morrison, Alanna C. | |
| dc.contributor.author | Navarro, Pau | |
| dc.contributor.author | Porteous, David J. | |
| dc.contributor.author | Pramstaller, Peter P. | |
| dc.contributor.author | Reiner, Alexander P. | |
| dc.contributor.author | Risch, Lorenz | |
| dc.contributor.author | Schotten, Ulrich | |
| dc.contributor.author | Shen, Xia | |
| dc.contributor.author | Sinagra, Gianfranco | |
| dc.contributor.author | Soliman, Elsayed Z. | |
| dc.contributor.author | Stoll, Monika | |
| dc.contributor.author | Tarazona-Santos, Eduardo | |
| dc.contributor.author | Tinker, Andrew | |
| dc.contributor.author | Trajanoska, Katerina | |
| dc.contributor.author | Villard, Eric | |
| dc.contributor.author | Warren, Helen R. | |
| dc.contributor.author | Whitsel, Eric A. | |
| dc.contributor.author | Wiggins, Kerri L. | |
| dc.contributor.author | Arking, Dan E. | |
| dc.contributor.author | Avery, Christy L. | |
| dc.contributor.author | Conen, David | |
| dc.contributor.author | Girotto, Giorgia | |
| dc.contributor.author | Grarup, Niels | |
| dc.contributor.author | Hayward, Caroline | |
| dc.contributor.author | Jukema, J.Wouter | |
| dc.contributor.author | Mook-Kanamori, Dennis O. | |
| dc.contributor.author | Olesen, Morten Salling | |
| dc.contributor.author | Padmanabhan, Sandosh | |
| dc.contributor.author | Psaty, Bruce M. | |
| dc.contributor.author | Pattaro, Cristian | |
| dc.contributor.author | Ribeiro, Antonio Luiz P. | |
| dc.contributor.author | Rotter, Jerome I. | |
| dc.contributor.author | Stricker, Bruno H. | |
| dc.contributor.author | van der Harst, Pim | |
| dc.contributor.author | van Duijn, Cornelia M. | |
| dc.contributor.author | Verweij, Niek | |
| dc.contributor.author | Wilson, James G. | |
| dc.contributor.author | Orini, Michele | |
| dc.contributor.author | Charron, Philippe | |
| dc.contributor.author | Watkins, Hugh | |
| dc.contributor.author | Kooperberg, Charles | |
| dc.contributor.author | Lin, Henry J. | |
| dc.contributor.author | Wilson, James F. | |
| dc.contributor.author | Kanters, Jørgen K. | |
| dc.contributor.author | Sotoodehnia, Nona | |
| dc.contributor.author | Mifsud, Borbala | |
| dc.contributor.author | Lambiase, Pier D. | |
| dc.contributor.author | Tereshchenko, Larisa G. | |
| dc.contributor.author | Munroe, Patricia B. | |
| dc.date.accessioned | 2023-04-16T04:38:14Z | |
| dc.date.available | 2023-04-16T04:38:14Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/13379 | |
| dc.description.abstract | The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction. © 2023, The Author(s). | en_US |
| dc.language.iso | eng | |
| dc.publisher | Nature Research | |
| dc.relation.ispartofseries | Nature Communications | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Humans | en_US |
| dc.subject | Risk Factors | en_US |
| dc.subject | Biomarkers | en_US |
| dc.subject | *Atrioventricular Block | en_US |
| dc.subject | *Cardiovascular Diseases/genetics | en_US |
| dc.subject | Arrhythmias, Cardiac/genetics | en_US |
| dc.subject | Electrocardiography/methods | en_US |
| dc.subject | Genome-Wide Association Study | en_US |
| dc.title | Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1038/s41467-023-36997-w | |
| dc.relation.issn | 2041-1723 |
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