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Reproducibility of peripapillary, optic nerve head and macular vessel density by OCT-A according to glaucoma severity staging.

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dc.contributor.author Salazar-Quiñones, L.
dc.contributor.author Peña-Urbina, P.
dc.contributor.author Fernández-Vigo, J. I.
dc.contributor.author Pérez Quiñones, Yadhira Maytee
dc.contributor.author Molero-Senosiain, M.
dc.contributor.author Mendez-Hernandez, C.
dc.contributor.author Martínez-de-la-Casa, J. M.
dc.contributor.author García-Feijóo, J.
dc.date.accessioned 2023-04-16T04:38:15Z
dc.date.available 2023-04-16T04:38:15Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13401
dc.description.abstract OBJECTIVE: To assess the reproducibility of peripapillary, optic nerve head (ONH-PP) and macular vessel density (VD) by Spectral Domain optical coherence tomography angiography (SD OCT-A) in glaucoma patients and healthy subjects. METHODS: Cross-sectional study assessing 63 eyes of 63 subjects, including 33 glaucoma patients and 30 healthy subjects. Glaucoma was classified in mild, moderate, or advanced. Two consecutive scans were acquired by Spectralis Module OCT-A (Heidelberg, Germany), and provided images of the superficial vascular complex (SVC), nerve fiber layer vascular plexus (NFLVP), superficial vascular plexus (SVP); deep vascular complex (DVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP). VD (%) was calculated by AngioTool. Intraclass correlation coefficients (ICCs) and coefficients of variation (CV) were calculated. RESULTS: Among ONH-PP VD, better ICC presented advanced (0.83-0.97) and moderate glaucoma (0.86-0.96) compared with mild glaucoma (0.64-0.86). For the macular VD reproducibility, ICC results for superficial retinal layers were better for mild glaucoma (0.94-0.96) followed by moderated (0.88-0.93) and advanced glaucoma (0.85-0.91), and for deeper retinal layers ICC was better for moderate glaucoma (0.96-0.95) followed by advanced (0.80-0.86) and mild glaucoma (0.74-0.91). CVs ranged from 2.2% to 10.94%. Among healthy subjects, ICCs for the ONH-PP VD measurements (0.91-0.99) and for the macular VD measurements (0.93-0.97) were excellent in all layers, with CVs from 1.65% to 10.33%. CONCLUSIONS: SD OCT-A used to quantify macular and ONH-PP VD showed excellent and good reproducibility in most layers of the retina, both in healthy subjects and in glaucoma patients regardless of the severity of the disease. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Archivos de la Sociedad Espanola de Oftalmologia
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Angiografía por tomografía de coherencia óptica es_PE
dc.subject Cabeza del nervio óptico y peripapilar es_PE
dc.subject Densidad vascular es_PE
dc.subject Macula es_PE
dc.subject Mácula es_PE
dc.subject Optic nerve head es_PE
dc.subject Optical coherence tomography angiography es_PE
dc.subject Peripapillary es_PE
dc.subject Reproducibilidad es_PE
dc.subject Reproducibility es_PE
dc.subject Vessel density es_PE
dc.title Reproducibility of peripapillary, optic nerve head and macular vessel density by OCT-A according to glaucoma severity staging. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.oftale.2023.04.002
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.22
dc.relation.issn 2173-5794


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