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Statistical analysis of 914 Mycobacterium tuberculosis genomes reveals single nucleotide polymorphisms in the ponA1 gene associated with rifampicin resistance

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dc.contributor.author Rabanal Sánchez, Jhonatan
dc.date.accessioned 2023-04-16T04:38:15Z
dc.date.available 2023-04-16T04:38:15Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13404
dc.description.abstract Rifampicin resistance in Mycobacterium tuberculosis represents a big public health problem and the ponA1 gene could be related to this. Our study analyzed three secondary databases of 914 M. tuberculosis genomes, which were obtained from samples taken from patients of Lima and Callao cities. The following statistical tests were used to determine statistical association: Chi-square test, prevalence ratio (PR), and odds ratio (OR). We found that the presence of at least one SNP in the ponA1 gene was statistically associated with rifampicin resistance (ρ-values ​​of Chi-square test and OR < 0,05) and it was more likely to find an SNP of this gene in susceptible strains than in rifampicin-resistant strains (ρ-value of PR < 0,05). Likewise, two SNPs (P631S and A516T) were statistically associated with rifampicin resistance (ρ-values ​​of Chi-square test and OR < 0,05). A516T was more likely in resistant strains than susceptible stains, the opposite was found in P631S (ρ-value of PR < 0,05). In conclusion, the SNP A516T is statistically associated with rifampicin resistance and could generate phenotypic changes, which could alter rifampicin tolerance. © 2022, The Author(s) under exclusive licence to Archana Sharma Foundation of Calcutta. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Nucleus (India)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Mycobacterium tuberculosis en_US
dc.subject ponA1 gene en_US
dc.subject Rifampicin en_US
dc.subject Single nucleotide polymorphisms en_US
dc.title Statistical analysis of 914 Mycobacterium tuberculosis genomes reveals single nucleotide polymorphisms in the ponA1 gene associated with rifampicin resistance en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s13237-022-00413-3
dc.relation.issn 0029-568X


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