Universidad Peruana Cayetano Heredia
The Increase in Hemoglobin Concentration With Altitude Differs Between World Regions and Is Less in Children Than in Adults.
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| dc.contributor.author | Mairbäurl, Heimo | |
| dc.contributor.author | Kilian, Samuel | |
| dc.contributor.author | Seide, Svenja | |
| dc.contributor.author | Muckenthaler, Martina U. | |
| dc.contributor.author | Gassmann Mendez, Max | |
| dc.contributor.author | Benedict, Rukundo K. | |
| dc.coverage.spatial | Guatemala | |
| dc.coverage.spatial | Honduras | |
| dc.coverage.spatial | Perú | |
| dc.coverage.spatial | Bolivia | |
| dc.coverage.spatial | Angola | |
| dc.coverage.spatial | Chad | |
| dc.coverage.spatial | Camerún | |
| dc.coverage.spatial | Guinea | |
| dc.coverage.spatial | Lesotho | |
| dc.coverage.spatial | Namibia | |
| dc.coverage.spatial | Esuatini | |
| dc.coverage.spatial | Sudáfrica | |
| dc.coverage.spatial | Burundi | |
| dc.coverage.spatial | Etiopia | |
| dc.coverage.spatial | Kenia | |
| dc.coverage.spatial | Madagascar | |
| dc.coverage.spatial | Malawi | |
| dc.coverage.spatial | Mozambique | |
| dc.coverage.spatial | Ruanda | |
| dc.coverage.spatial | Tanzania | |
| dc.coverage.spatial | Uganda | |
| dc.coverage.spatial | Zimbabwe | |
| dc.coverage.spatial | Jordania | |
| dc.coverage.spatial | Yemen | |
| dc.coverage.spatial | Armenia | |
| dc.coverage.spatial | Azerbaiyán | |
| dc.coverage.spatial | Kirguistán | |
| dc.coverage.spatial | Tajikistán | |
| dc.coverage.spatial | India | |
| dc.coverage.spatial | Birmania | |
| dc.coverage.spatial | Nepal | |
| dc.coverage.spatial | Timor Oriental | |
| dc.date.accessioned | 2023-04-16T04:38:16Z | |
| dc.date.available | 2023-04-16T04:38:16Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/13413 | |
| dc.description.abstract | To compensate for decreased oxygen partial pressure, high-altitude residents increase hemoglobin concentrations [Hb]. The elevation varies between world regions, posing problems in defining cutoff values for anemia or polycythemia. The currently used altitude adjustments (World Health Organization [WHO]), however, do not account for regional differences. Data from The Demographic and Health Survey (DHS) Program were analyzed from 32 countries harboring >4% of residents at altitudes above 1000 m. [Hb]-increase, (ΔHb/km altitude) was calculated by linear regression analysis. Tables show 95% reference intervals (RIs) for different altitude ranges, world regions, and age groups. The prevalence of anemia and polycythemia was calculated using regressions in comparison to WHO adjustments. The most pronounced Δ[Hb]/km was found in East Africans and South Americans while [Hb] increased least in South/South-East Asia. In African regions and Middle East, [Hb] was decreased in some altitude regions showing inconsistent changes in different age groups. Of note, in all regions, the Δ[Hb]/km was lower in children than in adults, and in the Middle East, it was even negative. Overall, the Δ[Hb]/km from our analysis differed from the region-independent adjustments currently suggested by the WHO resulting in a lower anemia prevalence at very high altitudes. The distinct patterns of Δ[Hb] with altitude in residents from different world regions imply that one single, region-independent correction factor for altitude is not be applicable for diagnosing abnormal [Hb]. Therefore, we provide regression coefficients and reference-tables that are specific for world regions and altitude ranges to improve diagnosing abnormal [Hb]. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Wolters Kluwer Health | |
| dc.relation.ispartofseries | HemaSphere | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Hemoglobin Concentration | en_US |
| dc.subject | Altitude | en_US |
| dc.subject | World Regions | en_US |
| dc.subject | Children | en_US |
| dc.subject | Adults | en_US |
| dc.title | The Increase in Hemoglobin Concentration With Altitude Differs Between World Regions and Is Less in Children Than in Adults. | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1097/HS9.0000000000000854 | |
| dc.relation.issn | 2572-9241 |
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