Universidad Peruana Cayetano Heredia

Amplicon sequencing reveals complex infection in infants congenitally infected with Trypanosoma cruzi and informs the dynamics of parasite transmission.

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dc.contributor.author Hakim, Jill M. C.
dc.contributor.author Waltmann, Andreea
dc.contributor.author Tinajeros, Freddy
dc.contributor.author Kharabora, Oksana
dc.contributor.author Málaga Machaca, Edith Silvia
dc.contributor.author Calderón Sánchez, Maritza Mercedes
dc.contributor.author Menduiña, María Del Carmen
dc.contributor.author Wang, Jeremy
dc.contributor.author Rueda, Daniel
dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Verastegui Pimentel, Manuela Renee
dc.contributor.author Juliano, Jonathan J.
dc.contributor.author Gilman, Robert H.
dc.contributor.author Mugnier, Monica R.
dc.contributor.author Bowman, Natalie M.
dc.date.accessioned 2023-05-19T14:08:33Z
dc.date.available 2023-05-19T14:08:33Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13523
dc.description.abstract Congenital transmission of Trypanosoma cruzi is an important source of new Chagas infections worldwide. The mechanisms of congenital transmission remain poorly understood, but there is evidence that parasite factors are involved. Investigating changes in parasite strain diversity during transmission could provide insight into the parasite factors that influence the process. Here we use amplicon sequencing of a single copy T. cruzi gene to evaluate the diversity of infection in clinical samples from Chagas positive mothers and their infected infants. Several infants and mothers were infected with multiple parasite strains, mostly of the same TcV lineage, and parasite strain diversity was higher in infants than mothers. Two parasite haplotypes were detected exclusively in infant samples, while one haplotype was never found in infants. Together, these data suggest multiple parasites initiate a congenital infection and that parasite factors influence the probability of vertical transmission. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Amplicon sequencing en_US
dc.subject Congenital Chagas en_US
dc.subject Trypanosoma cruzi en_US
dc.subject.mesh Análisis de Secuencia de ADN
dc.subject.mesh Enfermedad de Chagas
dc.subject.mesh Trypanosoma cruzi
dc.title Amplicon sequencing reveals complex infection in infants congenitally infected with Trypanosoma cruzi and informs the dynamics of parasite transmission. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/infdis/jiad125
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6613


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