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SARS-CoV-2 antibody status at time of delivery and the risk of preeclampsia.

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dc.contributor.author Portmann Baracco, Arianna Sibila
dc.contributor.author Alcorta Proaño, Rodrigo Gerónimo
dc.contributor.author Nuñez Mochizaki, Claudia
dc.contributor.author Webb Camminati, Camille María
dc.contributor.author Trelles Yenque, Juan Gualberto
dc.contributor.author Caparo Farfán, Carlos Alberto
dc.contributor.author La Rosa de los Rios, Mauricio Francisco
dc.date.accessioned 2023-06-12T16:25:54Z
dc.date.available 2023-06-12T16:25:54Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13602
dc.description.abstract OBJECTIVE: Evaluate the association between SARS-CoV-2 serologic status in immunologically naïve patients and risk of preeclampsia at time of delivery. STUDY DESIGN: We conducted a retrospective cohort study of pregnant patients admitted to our institution from August 1st to September 30th, 2020. We recorded maternal medical and obstetric characteristics, and SARS-CoV-2 serologic status. Our primary outcome was the incidence of preeclampsia. Antibody testing was performed and patients were classified into seropositive groups: IgG+, IgM+, or both IgG+ and IgM+. Bivariate and multivariable analyses were performed. RESULTS: We included 275 patients that were negative for SARS-CoV-2 antibodies, and 165 that were positive. Seropositivity was not associated with higher rates of preeclampsia (p=0.183), or with preeclampsia with severe features (p=0.916) even after adjusting for maternal age> 35, BMI≥ 30, nulliparity, and previous history of preeclampsia, and type of serologic status. Previous preeclampsia had the greatest association with development of preeclampsia (OR=13.40 95% CI [4.98-36.09]; p< 0.05), and with preeclampsia with severe features (OR=5.46 95% CI [1.65-18.02]; p< 0.05). CONCLUSIONS: We found that in an obstetric population there was no association between SARS-CoV-2 antibody status and the risk of preeclampsia. en_US
dc.language.iso eng
dc.publisher Georg Thieme Verlag KG
dc.relation.ispartofseries American Journal of Perinatology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject SARS-CoV-2 en_US
dc.subject Antibody en_US
dc.subject Delivery en_US
dc.subject Risk en_US
dc.subject Preeclampsia en_US
dc.subject.mesh SARS-CoV-2
dc.subject.mesh Parto Obstétrico
dc.subject.mesh Riesgo
dc.subject.mesh Preeclampsia
dc.title SARS-CoV-2 antibody status at time of delivery and the risk of preeclampsia. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1055/a-2099-8758
dc.relation.issn 1098-8785


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