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dc.contributor.author | Lopes, Fernando | |
dc.contributor.author | Oliveira, Larissa R. | |
dc.contributor.author | Beux, Yago | |
dc.contributor.author | Kessler, Amanda | |
dc.contributor.author | Cardenas Alayza, Susana | |
dc.contributor.author | Majluf Chiok, Maria Patricia | |
dc.contributor.author | Páez-Rosas, Diego | |
dc.contributor.author | Chaves, Jaime | |
dc.contributor.author | Crespo, Enrique | |
dc.contributor.author | Brownell, Robert L. Jr | |
dc.contributor.author | Baylis, Alastair M. M. | |
dc.contributor.author | Sepúlveda, Maritza | |
dc.contributor.author | Franco-Trecu, Valentina | |
dc.contributor.author | Loch, Carolina | |
dc.contributor.author | Robertson, Bruce C. | |
dc.contributor.author | Peart, Claire R. | |
dc.contributor.author | Wolf, Jochen B. W. | |
dc.contributor.author | Bonatto, Sandro L. | |
dc.coverage.spatial | Lima, Perú | |
dc.date.accessioned | 2023-06-12T16:25:57Z | |
dc.date.available | 2023-06-12T16:25:57Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/13641 | |
dc.description.abstract | Introduction: COVID-19 seems to induce ischemic stroke by several potential mechanisms including promoting hypercoagulability, and worse functional outcomes have been reported in patients with stroke and the infection with SARS-CoV-2. Objective: Determine the association between functional outcome and COVID-19 in patients with stroke. Patients and methods: We performed a case control study comparing patients admitted to a neurological reference center in Peru with a diagnosis of stroke before (controls) and after (cases) the onset of the COVID-19 pandemic. There were 31 cases diagnosed with COVID-19 and 62 controls without COVID-19. Bivariate analysis and conditional fixed-effects Poisson regression analysis were used to evaluate the association between the functional outcome of the stroke and COVID-19. Results: Cases had higher baseline serum glucose (133.5, IQR: 117.5-174 versus 117, IQR: 101-130, p = 0.033) than controls, higher neutrophil counts (7.91, IQR: 5.93-9.57 versus 5.96, IQR: 4.41-7.79, p = 0.008), lower lymphocyte counts (1.48, IQR: 1.04-1.8 versus 1.83, IQR: 1.26-2.32, p = 0.025), higher neutrophil/lymphocyte ratios (5.44, IQR: 4.0-8.1 versus 3.29, IQR: 2.25-6.02, p = 0.011), higher NIH stroke scale/score (NIHSS) (14, IQR: 9-18 versus 7 IQR: 5-11, p = 0.000), and higher modified Rankin scores at discharge (4, IQR: 4-5 versus 2, IQR: 1-4), p = 0.001). Seven (21.88%) participants died in the group of cases versus 1 (1.56%) in the controls (p = 0.014). The odds ratio of having a bad functional outcome at discharge was 1.344 (CI: 1.079-4.039; p = 0.029), adjusted by NIHSS at admission. Conclusions: Our findings suggest that ischemic strokes associated with COVID-19 are more severe, have worse functional outcome and higher mortality than non-COVID-19 ischemic strokes. | en_US |
dc.description.abstract | Introducción: El COVID-19 puede desencadenar un infarto cerebral por varios mecanismos potenciales, entre ellas, la hipercoagulabilidad. Se han reportado peores resultados funcionales en pacientes con infarto cerebral y COVID-19. Objetivo: Determinar la asociación entre resultado funcional y COVID-19 en pacientes con infarto cerebral isquémico. Pacientes y métodos: Se realizó un estudio de casos y controles comparando a pacientes ingresados a un centro de referencia neurológico en Perú con diagnóstico de infarto cerebral, antes (controles) y después (casos) del inicio de la pandemia por COVID-19. Hubo 31 casos diagnosticados con COVID-19 y 62 controles. Se utilizaron análisis bivariado y análisis de regresión de Poisson de efectos fijos condicionales. Resultados: Los casos tenían glucemia basal más alta (133,5, RIQ: 117,5-174 vs 117, RIQ: 101-130, p = 0,033) que los controles, recuentos de neutrófilos más altos (7,91, RIQ: 5,93-9,57 vs. 5,96, RIQ: 4,41-7,79, p = 0,008), menor recuento de linfocitos (1,48, RIQ: 1,04-1,8 frente a 1,83, RIQ: 1,26-2,32, p = 0,025), mayor relación neutrófilos/linfocitos (5,44, RIQ: 4,0-8,1 frente a 3,29, RIQ: 2,25-6,02, p = 0,011), mayor NIH scale/score (NIHSS) (14, RIQ: 9-18 vs. 7, RIQ: 5-11, p = 0,000) y mayores puntuaciones de Rankin modificadas al alta (4, RIQ: 4-5 vs. 2, RIQ: 1-4) p = 0,001). Siete (21,88%) participantes fallecieron en el grupo de casos vs. 1 (1,56%) en los controles (p = 0,014). La odds ratio de un mal resultado funcional al alta fue de 1,344 (IC: 1,079-4,039; p = 0,029), ajustada por NIHSS al ingreso. Conclusiones: Nuestros hallazgos sugieren que los infartos cerebrales asociados a COVID-19 son más graves, tienen un peor resultado funcional y una mayor mortalidad que los infartos cerebrales no relacionados a COVID-19. | es_PE |
dc.language.iso | spa | |
dc.publisher | Ediciones Doyma, S.L. | |
dc.relation.ispartofseries | Neurologia Argentina | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Infarto Cerebral | es_PE |
dc.subject | COVID-19 | es_PE |
dc.subject | Lima | es_PE |
dc.subject | Perú | es_PE |
dc.subject.mesh | Infarto Cerebral | |
dc.subject.mesh | COVID-19 | |
dc.subject.mesh | Perú | |
dc.title | Resultado funcional en pacientes con infarto cerebral y COVID-19 en Lima, Perú | es_PE |
dc.title.alternative | Functional outcome in patients with ischemic stroke and COVID-19 in Lima, Peru | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1016/j.neuarg.2023.03.003 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.25 | |
dc.relation.issn | 1853-0028 |
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