dc.contributor.author |
Crossay, Elise |
|
dc.contributor.author |
Jullian, Valérie |
|
dc.contributor.author |
Trinel, Manon |
|
dc.contributor.author |
Sagnat, David |
|
dc.contributor.author |
Hamel, Dimitri |
|
dc.contributor.author |
Groppi, Emie |
|
dc.contributor.author |
Rolland, Corinne |
|
dc.contributor.author |
Stigliani, Jean-Luc |
|
dc.contributor.author |
Mejia, Kember |
|
dc.contributor.author |
Cabanillas Amado, Billy Joel |
|
dc.contributor.author |
Alric, Laurent |
|
dc.contributor.author |
Buscail, Etienne |
|
dc.contributor.author |
El Kalamouni, Chaker |
|
dc.contributor.author |
Mavingui, Patrick |
|
dc.contributor.author |
Deraison, Céline |
|
dc.contributor.author |
Racaud-Sultan, Claire |
|
dc.contributor.author |
Fabre, Nicolas |
|
dc.date.accessioned |
2023-07-18T16:18:54Z |
|
dc.date.available |
2023-07-18T16:18:54Z |
|
dc.date.issued |
2023 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/13906 |
|
dc.description.abstract |
Hura crepitans L. (Euphorbiaceae) is a thorn-covered tree widespread in South America, Africa and Asia which produces an irritating milky latex containing numerous secondary metabolites, notably daphnane-type diterpenes known as Protein Kinase C activators. Fractionation of a dichloromethane extract of the latex led to the isolation of five new daphnane diterpenes (1-5), along with two known analogs (6-7) including huratoxin. Huratoxin (6) and 4',5'-epoxyhuratoxin (4) were found to exhibit significant and selective cell growth inhibition against colorectal cancer cell line Caco-2 and primary colorectal cancer cells cultured as colonoids. The underlying mechanism of 4 and 6 was further investigated revealing the involvement of PKCζ in the cytostatic activity. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Bioorganic & Medicinal Chemistry |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Euphorbiaceae |
en_US |
dc.subject |
Hura crepitans |
en_US |
dc.subject |
Daphnane diterpenes |
en_US |
dc.subject |
Colorectal cancer |
en_US |
dc.subject |
Caco-2 cells |
en_US |
dc.subject |
Protein Kinase C |
en_US |
dc.subject.mesh |
Euphorbiaceae |
|
dc.subject.mesh |
Hura crepitans |
|
dc.subject.mesh |
Diterpenos |
|
dc.subject.mesh |
Neoplasias Colorrectales |
|
dc.subject.mesh |
Células CACO-2 |
|
dc.subject.mesh |
Proteína Quinasa C |
|
dc.title |
Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells. |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1016/j.bmc.2023.117366 |
|
dc.relation.issn |
1464-3391 |
|