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Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells.

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dc.contributor.author Crossay, Elise
dc.contributor.author Jullian, Valérie
dc.contributor.author Trinel, Manon
dc.contributor.author Sagnat, David
dc.contributor.author Hamel, Dimitri
dc.contributor.author Groppi, Emie
dc.contributor.author Rolland, Corinne
dc.contributor.author Stigliani, Jean-Luc
dc.contributor.author Mejia, Kember
dc.contributor.author Cabanillas Amado, Billy Joel
dc.contributor.author Alric, Laurent
dc.contributor.author Buscail, Etienne
dc.contributor.author El Kalamouni, Chaker
dc.contributor.author Mavingui, Patrick
dc.contributor.author Deraison, Céline
dc.contributor.author Racaud-Sultan, Claire
dc.contributor.author Fabre, Nicolas
dc.date.accessioned 2023-07-18T16:18:54Z
dc.date.available 2023-07-18T16:18:54Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13906
dc.description.abstract Hura crepitans L. (Euphorbiaceae) is a thorn-covered tree widespread in South America, Africa and Asia which produces an irritating milky latex containing numerous secondary metabolites, notably daphnane-type diterpenes known as Protein Kinase C activators. Fractionation of a dichloromethane extract of the latex led to the isolation of five new daphnane diterpenes (1-5), along with two known analogs (6-7) including huratoxin. Huratoxin (6) and 4',5'-epoxyhuratoxin (4) were found to exhibit significant and selective cell growth inhibition against colorectal cancer cell line Caco-2 and primary colorectal cancer cells cultured as colonoids. The underlying mechanism of 4 and 6 was further investigated revealing the involvement of PKCζ in the cytostatic activity. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Bioorganic & Medicinal Chemistry
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Euphorbiaceae en_US
dc.subject Hura crepitans en_US
dc.subject Daphnane diterpenes en_US
dc.subject Colorectal cancer en_US
dc.subject Caco-2 cells en_US
dc.subject Protein Kinase C en_US
dc.subject.mesh Euphorbiaceae
dc.subject.mesh Hura crepitans
dc.subject.mesh Diterpenos
dc.subject.mesh Neoplasias Colorrectales
dc.subject.mesh Células CACO-2
dc.subject.mesh Proteína Quinasa C
dc.title Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.bmc.2023.117366
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.06
dc.relation.issn 1464-3391


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