Universidad Peruana Cayetano Heredia
Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells.
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| dc.contributor.author | Crossay, Elise | |
| dc.contributor.author | Jullian, Valérie | |
| dc.contributor.author | Trinel, Manon | |
| dc.contributor.author | Sagnat, David | |
| dc.contributor.author | Hamel, Dimitri | |
| dc.contributor.author | Groppi, Emie | |
| dc.contributor.author | Rolland, Corinne | |
| dc.contributor.author | Stigliani, Jean-Luc | |
| dc.contributor.author | Mejia, Kember | |
| dc.contributor.author | Cabanillas Amado, Billy Joel | |
| dc.contributor.author | Alric, Laurent | |
| dc.contributor.author | Buscail, Etienne | |
| dc.contributor.author | El Kalamouni, Chaker | |
| dc.contributor.author | Mavingui, Patrick | |
| dc.contributor.author | Deraison, Céline | |
| dc.contributor.author | Racaud-Sultan, Claire | |
| dc.contributor.author | Fabre, Nicolas | |
| dc.date.accessioned | 2023-07-18T16:18:54Z | |
| dc.date.available | 2023-07-18T16:18:54Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/13906 | |
| dc.description.abstract | Hura crepitans L. (Euphorbiaceae) is a thorn-covered tree widespread in South America, Africa and Asia which produces an irritating milky latex containing numerous secondary metabolites, notably daphnane-type diterpenes known as Protein Kinase C activators. Fractionation of a dichloromethane extract of the latex led to the isolation of five new daphnane diterpenes (1-5), along with two known analogs (6-7) including huratoxin. Huratoxin (6) and 4',5'-epoxyhuratoxin (4) were found to exhibit significant and selective cell growth inhibition against colorectal cancer cell line Caco-2 and primary colorectal cancer cells cultured as colonoids. The underlying mechanism of 4 and 6 was further investigated revealing the involvement of PKCζ in the cytostatic activity. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartofseries | Bioorganic & Medicinal Chemistry | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Euphorbiaceae | en_US |
| dc.subject | Hura crepitans | en_US |
| dc.subject | Daphnane diterpenes | en_US |
| dc.subject | Colorectal cancer | en_US |
| dc.subject | Caco-2 cells | en_US |
| dc.subject | Protein Kinase C | en_US |
| dc.subject.mesh | Euphorbiaceae | |
| dc.subject.mesh | Hura crepitans | |
| dc.subject.mesh | Diterpenos | |
| dc.subject.mesh | Neoplasias Colorrectales | |
| dc.subject.mesh | Células CACO-2 | |
| dc.subject.mesh | Proteína Quinasa C | |
| dc.title | Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells. | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1016/j.bmc.2023.117366 | |
| dc.relation.issn | 1464-3391 |
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