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Pneumococcal serotypes and antibiotic resistance in healthy carriage children after introduction of PCV13 in Lima, Peru.

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dc.contributor.author Gonzales Jaimes, Brayan Enrique
dc.contributor.author Mercado Zarate, Erik Hernan
dc.contributor.author Castillo Tokumori, Franco
dc.contributor.author Montero Quiñe, Andrea Estefania
dc.contributor.author Luna Muschi, Alessandra Joanna
dc.contributor.author Marcelo Ragas, Madhelli Natividad
dc.contributor.author Campos, Francisco
dc.contributor.author Chaparro Dammert, Luis Eduardo
dc.contributor.author Del Águila, Olguita
dc.contributor.author Castillo Díaz, María Esther
dc.contributor.author Saenz, Andrés
dc.contributor.author Reyes, Isabel
dc.contributor.author Hernandez, Roger
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.coverage.spatial Lima, Perú
dc.date.accessioned 2023-07-18T16:18:55Z
dc.date.available 2023-07-18T16:18:55Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13913
dc.description.abstract OBJECTIVE: To determinate the frequency of Streptococcus pneumoniae nasopharyngeal carriers, serotypes and antimicrobial resistance in healthy children in Lima, Peru, post-PCV13 introduction and to compare the results with a similar study conducted between 2006 and 2008 before PCV7 introduction (pre-PCV7). METHODS: A cross-sectional multicenter study was conducted between January 2018 and August 2019 in 1000 healthy children under two years of age. We use standard microbiological methods to determinate S. pneumoniae from nasopharyngeal swab, Kirby Bauer and minimum inhibitory concentration methods to determinate antimicrobial susceptibility and whole genomic sequencing to determinate pneumococcal serotypes. RESULTS: The pneumococcal carriage rate was 20.8 % vs. 31.1 % in pre-PCV7 (p < 0.001). The most frequent serotypes were 15C, 19A and 6C (12.4 %, 10.9 % and 10.9 % respectively). The carriage of PCV13 serotypes after PCV13 introduction decreased from 59.1 % (before PCV7 introduction) to 18.7 % (p < 0.001). Penicillin resistance was 75.5 %, TMP/SMX 75.5 % and azithromycin 50.0 %, using disk diffusion. Penicillin resistance rates using MIC breakpoint for meningitis (MIC ≥ 0.12) increased from 60.4 % to 74.5 % (p = 0.001). CONCLUSION: The introduction of PCV13 in the immunization program in Peru has decreased the pneumococcal nasopharyngeal carriage and the frequency of PCV13 serotypes; however, there has been an increase in non-PCV13 serotypes and antimicrobial resistance. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Vaccine (Amsterdam)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Streptococcus pneumoniae en_US
dc.subject Nasopharyngeal carriers en_US
dc.subject Pneumococcal conjugate vaccine en_US
dc.subject Serotypes en_US
dc.subject Antimicrobial resistance en_US
dc.subject.mesh Streptococcus pneumoniae
dc.subject.mesh Enfermedades Nasofaríngeas
dc.subject.mesh Vacuna Neumocócica Conjugada Heptavalente
dc.subject.mesh Serogrupo
dc.subject.mesh Farmacorresistencia Microbiana
dc.title Pneumococcal serotypes and antibiotic resistance in healthy carriage children after introduction of PCV13 in Lima, Peru. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.vaccine.2023.05.042
dc.relation.issn 1873-2518


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