Universidad Peruana Cayetano Heredia

Evaluating the Diagnostic Performance of Hemoglobin in the Diagnosis of Iron Deficiency Anemia in High-Altitude Populations: A Scoping Review.

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dc.contributor.author Vásquez Velásquez, Cinthya Margarita
dc.contributor.author Fernandez-Guzman, Daniel
dc.contributor.author Quispe-Vicuña, Carlos
dc.contributor.author Caira-Chuquineyra, Brenda
dc.contributor.author Ccami-Bernal, Fabricio
dc.contributor.author Castillo-Gutierrez, Piero
dc.contributor.author Arredondo-Nontol, Miriam
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2023-07-18T16:18:56Z
dc.date.available 2023-07-18T16:18:56Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/13928
dc.description.abstract We evaluated the available literature on the diagnostic performance of hemoglobin (Hb) in the diagnosis of iron deficiency anemia (IDA) in high-altitude populations. We searched PubMed, Web of Science, Scopus, Embase, Medline by Ovid, the Cochrane Library, and LILCAS until 3 May 2022. We included studies that evaluated the diagnostic performance (sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), receiver operating characteristic (ROC) curves, and accuracy) of Hb (with and without an altitude correction factor) compared to any iron deficiency (ID) marker (e.g., ferritin, soluble transferrin receptor (sTFR), transferrin saturation, or total body iron (TBI)) in populations residing at altitudes (≥1000 m above sea level). We identified a total of 14 studies (with 4522 participants). We found disagreement in diagnostic performance test values between the studies, both in those comparing hemoglobin with and in those comparing hemoglobin without a correction factor for altitude. Sensitivity ranged from 7% to 100%, whereas specificity ranged from 30% to 100%. Three studies reported higher accuracy of uncorrected versus altitude-corrected hemoglobin. Similarly, two studies found that not correcting hemoglobin for altitude improved the receiver operating characteristic (ROC) curves for the diagnosis of iron deficiency anemia. Available studies on high-altitude populations suggest that the diagnostic accuracy of Hb is higher when altitude correction is not used. In addition, the high prevalence of anemia in altitude regions could be due to diagnostic misclassification. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries International Journal of Environmental Research and Public Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Altitude en_US
dc.subject Hemoglobin en_US
dc.subject Iron deficiency anemia en_US
dc.subject Scoping review en_US
dc.subject Accuracy en_US
dc.subject ROC curves en_US
dc.subject.mesh Altitud
dc.subject.mesh Hemoglobinas
dc.subject.mesh Anemia Ferropénica
dc.subject.mesh Revisión
dc.subject.mesh Exactitud de los Datos
dc.subject.mesh Curva ROC
dc.title Evaluating the Diagnostic Performance of Hemoglobin in the Diagnosis of Iron Deficiency Anemia in High-Altitude Populations: A Scoping Review. en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.3390/ijerph20126117
dc.relation.issn 1661-7827


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