dc.contributor.advisor |
Cabello Morales, Emilio Andrés |
es_ES |
dc.contributor.advisor |
Loza Munarriz, César Antonio |
es_ES |
dc.contributor.author |
Orellana Cabello, Adriana Ursula |
es_ES |
dc.contributor.author |
Romero Rodriguez, Andrea Lizeth |
es_ES |
dc.date.accessioned |
2023-07-31T16:19:20Z |
|
dc.date.available |
2023-07-31T16:19:20Z |
|
dc.date.issued |
2023 |
|
dc.identifier.other |
206948 |
es_ES |
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/13949 |
|
dc.description.abstract |
El hipotiroidismo autoinmune es una patología frecuente en niños y adolescentes; sin embargo, no existe consenso sobre su diagnóstico dentro del amplio espectro de las tiroiditis autoinmunes. Objetivo: Describir las características clínicas, bioquímicas y radiológicas al diagnóstico de los niños y adolescentes con hipotiroidismo autoinmune atendidos en un hospital de Lima 2014-2019. Materiales y métodos: Serie de casos. Se revisaron historias clínicas de pacientes con diagnóstico de hipotiroidismo autoinmune. Se excluyeron pacientes con síndrome dismorfogenético, enfermedad crónica, uso de medicamentos e hipotiroidismo agudo o subagudo. Se recopilaron datos clínicos, laboratoriales y radiológicos al diagnóstico. Se estimó el Z-talla, Z-talla genética y Z-IMC. Se realizó estadística descriptiva y T de Student con Stata 17, p significativo < 0,05. Resultados: Se incluyeron 38 pacientes. El promedio de edad fue 9,63 ± 3,13 años, sexo femenino (89,5%), estadio puberal (60.5%), motivo de consulta: bocio (52,6%). Grado de bocio: I (34,6%), II (34,6%) y III (30,8%). Normopeso 52,7%, sobrepeso 21%, y obesidad 26,3%. El 89,5% y 94,8% presentaron escolaridad y desarrollo psicomotor adecuados. 31,8% tuvo antecedente familiar. El Z-talla fue significativamente mayor que el Z-talla genética. No hubo diferencia significativa entre la edad ósea y la cronológica. El 86,9% presentó anticuerpos positivos. Conclusiones: El bocio fue el signo más frecuente, la mayoría no presentó trastorno de crecimiento, alteración del estado nutricional ni retraso de la edad ósea. Un tercio presentó antecedente familiar de tiropatía. La ausencia de anti TPO y anti TG no descartó el diagnóstico de hipotiroidismo autoinmune. |
es_ES |
dc.description.abstract |
Autoimmune hypothyroidism is a frequent pathology in children and adolescents; however, there is no consensus on its diagnosis within the broad spectrum of autoimmune thyroiditis. Objective: To describe the clinical, biochemical and radiological characteristics at diagnosis of children and adolescents with autoimmune hypothyroidism treated at a hospital in Lima from 2014 to 2019. Materials and methods: Case series. The clinical histories of patients with a diagnosis of autoimmune hypothyroidism were reviewed. Patients with dysmorphogenetic syndrome, chronic disease, use of medications, and acute or subacute hypothyroidism were excluded. Clinical, laboratory and radiological data were collected at diagnosis. Z-height, Z-genetic height and Z-IMC were estimated. Descriptive statistics and T-test with Stata 17 were performed. p < 0.05 was considered significant. Results: The mean age was 9.63 ± 3.13 years, female sex (89.5%), pubertal stage (60.5%), reason for consultation: goiter (52.6%). Goiter grade: I (34.6%), II (34.6%) and III (30.8%). Normal weight 52.7%, overweight 21%, and obesity 26.3%. 76.3% and 94.8% presented adequate scholar performance and psychomotor development. 31.8% had a family history. The Z-height was significantly higher than the genetic Z-height. There was no significant difference between bone and chronological age. 86.9% presented positive antibodies. Conclusions: Goiter was the most frequent sign, the majority didn’t present growth disorder, nutritional status alteration or bone age delay. One third had a family history of thyropathy. The absence of anti TPO and anti TG didn’t rule out the diagnosis of autoimmune hypothyroidism. |
es_ES |
dc.format |
application/pdf |
es_ES |
dc.language.iso |
spa |
es_ES |
dc.publisher |
Universidad Peruana Cayetano Heredia |
es_ES |
dc.rights |
info:eu-repo/semantics/openAccess |
es_ES |
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
es_ES |
dc.subject |
Tiroiditis Autoinmune |
es_ES |
dc.subject |
Hipotiroidismo |
es_ES |
dc.subject |
Niños |
es_ES |
dc.title |
Características clínicas, bioquímicas y radiológicas de niños y adolescentes con diagnóstico de hipotiroidismo autoinmune atendidos en un hospital público de Lima 2014-2019 |
es_ES |
dc.title.alternative |
Clinical, biochemical and radiological characteristics of children and adolescents diagnosed with autoimmune hypothyroidism attended at a public hospital in Lima 2014 - 2019 |
es_ES |
dc.type |
info:eu-repo/semantics/bachelorThesis |
es_ES |
thesis.degree.name |
Médico Cirujano |
es_ES |
thesis.degree.grantor |
Universidad Peruana Cayetano Heredia. Facultad de Medicina Alberto Hurtado |
es_ES |
thesis.degree.discipline |
Medicina |
es_ES |
dc.publisher.country |
PE |
es_ES |
dc.subject.ocde |
http://purl.org/pe-repo/ocde/ford#3.01.03 |
es_ES |
dc.subject.ocde |
http://purl.org/pe-repo/ocde/ford#3.02.03 |
es_ES |
dc.subject.ocde |
http://purl.org/pe-repo/ocde/ford#3.02.18 |
es_ES |
renati.author.dni |
71583916 |
|
renati.author.dni |
76208988 |
|
renati.advisor.orcid |
https://orcid.org/0000-0001-7849-8273 |
es_ES |
renati.advisor.orcid |
https://orcid.org/0000-0003-4545-9969 |
es_ES |
renati.advisor.dni |
10291113 |
|
renati.advisor.dni |
21456043 |
|
renati.type |
http://purl.org/pe-repo/renati/type#tesis |
es_ES |
renati.level |
http://purl.org/pe-repo/renati/nivel#tituloProfesional |
es_ES |
renati.discipline |
912016 |
es_ES |
renati.juror |
Guillén Pinto, Rosendo Daniel |
es_ES |
renati.juror |
Mas Ubillús, Guiliana |
es_ES |
renati.juror |
Rado Peralta, Sandra Cecilia |
es_ES |