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Evaluation of 1-hour post load glucose levels, the metabolic syndrome and findrisc scores in the prediction of T2DM in patients with impaired fasting glucose

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dc.contributor.author Lizarzaburu-Robles, JC
dc.contributor.author Garro-Mendiola, A
dc.contributor.author Lazo Porras, María de los Ángeles
dc.contributor.author Vento, F
dc.contributor.author Lorenzo, O
dc.date.accessioned 2023-09-06T20:45:07Z
dc.date.available 2023-09-06T20:45:07Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14051
dc.description.abstract Background: Early detection of subjects at risk for type 2 diabetes (T2DM) is critical to prevent or delay cardiometabolic complications. 1-Hour Post-Load Glucose(1h-PG) ≥155mg/dL, the Metabolic Syndrome (MS) and FINDRISC (FR) score need more studies to predict T2DM in individuals with normal glucose tolerance (NGT), in Latin American population. Aim: To evaluate 1h-PG≥155mg/dL, MS and FR scores in patients with impaired fasting glucose (IFG) to predict T2D at seven years (7yrs). Methodology: 218 consecutive subjects with IFG performed an oral glucose tolerant test (OGTT) and were followed-up for 7yrs. The outcome was diagnosis of T2DM, and the exposures were 1h-PG≥155mg/dL, MS and FR scores (≥13points) following the criteria of the Latin-American Diabetes-Association. Frequencies were described and the association between T2DM diagnosis with the exposures were explored using chi2 test. Relative risk (RR) was estimated using Poisson regression with 95%CIs. Results: The mean age was 56.2 ±11.5 years-old, and 64.0% of them were female. 63.8% were overweigh/obese. 66.8% had MS, 64.3% FR ≥13points, and 46.8% exhibited 1h-PG ≥155mg/dL. After 7yrs of follow-up, 21.1% developed T2DM, but only 25.2% and 20% of them had MS (p=0.049) and FR ≥13points (p=0.258) respectively. 33.3% exhibited 1h-PG ≥155mg/dL (p<0.001). When evaluating the association of T2DM with MS, FR ≥13points or 1h-PG ≥155mg/dL with NGT, the RR adjusting by gender and age were 2.07 (1.07–4.00; 95%CI), 1.42 (0.64-3.19; 95%CI) and 3.85 (1.97-7.52; 95%CI) respectively. Conclusion: 1h-PG ≥155mg/dL may predict T2DM better than the MS in individuals with IGF. Furthers analysis were required for FR. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Metabolism-Clinical and Experimental
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Oral Glucose tolerance test en_US
dc.subject Metabolic Syndrome en_US
dc.subject FINDRISC en_US
dc.subject 1hr Post load Glucose en_US
dc.subject.mesh Prueba de Tolerancia a la Glucosa
dc.subject.mesh Síndrome Metabólico
dc.title Evaluation of 1-hour post load glucose levels, the metabolic syndrome and findrisc scores in the prediction of T2DM in patients with impaired fasting glucose en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.metabol.2023.155509
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1532-8600


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