Universidad Peruana Cayetano Heredia
Evaluation of 1-hour post load glucose levels, the metabolic syndrome and findrisc scores in the prediction of T2DM in patients with impaired fasting glucose
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| dc.contributor.author | Lizarzaburu-Robles, JC | |
| dc.contributor.author | Garro-Mendiola, A | |
| dc.contributor.author | Lazo Porras, María de los Ángeles | |
| dc.contributor.author | Vento, F | |
| dc.contributor.author | Lorenzo, O | |
| dc.date.accessioned | 2023-09-06T20:45:07Z | |
| dc.date.available | 2023-09-06T20:45:07Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/14051 | |
| dc.description.abstract | Background: Early detection of subjects at risk for type 2 diabetes (T2DM) is critical to prevent or delay cardiometabolic complications. 1-Hour Post-Load Glucose(1h-PG) ≥155mg/dL, the Metabolic Syndrome (MS) and FINDRISC (FR) score need more studies to predict T2DM in individuals with normal glucose tolerance (NGT), in Latin American population. Aim: To evaluate 1h-PG≥155mg/dL, MS and FR scores in patients with impaired fasting glucose (IFG) to predict T2D at seven years (7yrs). Methodology: 218 consecutive subjects with IFG performed an oral glucose tolerant test (OGTT) and were followed-up for 7yrs. The outcome was diagnosis of T2DM, and the exposures were 1h-PG≥155mg/dL, MS and FR scores (≥13points) following the criteria of the Latin-American Diabetes-Association. Frequencies were described and the association between T2DM diagnosis with the exposures were explored using chi2 test. Relative risk (RR) was estimated using Poisson regression with 95%CIs. Results: The mean age was 56.2 ±11.5 years-old, and 64.0% of them were female. 63.8% were overweigh/obese. 66.8% had MS, 64.3% FR ≥13points, and 46.8% exhibited 1h-PG ≥155mg/dL. After 7yrs of follow-up, 21.1% developed T2DM, but only 25.2% and 20% of them had MS (p=0.049) and FR ≥13points (p=0.258) respectively. 33.3% exhibited 1h-PG ≥155mg/dL (p<0.001). When evaluating the association of T2DM with MS, FR ≥13points or 1h-PG ≥155mg/dL with NGT, the RR adjusting by gender and age were 2.07 (1.07–4.00; 95%CI), 1.42 (0.64-3.19; 95%CI) and 3.85 (1.97-7.52; 95%CI) respectively. Conclusion: 1h-PG ≥155mg/dL may predict T2DM better than the MS in individuals with IGF. Furthers analysis were required for FR. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartofseries | Metabolism-Clinical and Experimental | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Oral Glucose tolerance test | en_US |
| dc.subject | Metabolic Syndrome | en_US |
| dc.subject | FINDRISC | en_US |
| dc.subject | 1hr Post load Glucose | en_US |
| dc.subject.mesh | Prueba de Tolerancia a la Glucosa | |
| dc.subject.mesh | Síndrome Metabólico | |
| dc.title | Evaluation of 1-hour post load glucose levels, the metabolic syndrome and findrisc scores in the prediction of T2DM in patients with impaired fasting glucose | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1016/j.metabol.2023.155509 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.18 | |
| dc.relation.issn | 1532-8600 |
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