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Respiratory, Cardiac, and Neuropsychiatric Manifestations of Postacute Sequelae of Coronavirus Disease 2019 in Lima, Peru

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dc.contributor.author Rahman, Rifat S.
dc.contributor.author Tovar, Marco A.
dc.contributor.author Peinado, Jesús
dc.contributor.author Palomino, J. Santiago
dc.contributor.author Ramirez, Claudio
dc.contributor.author Llanos Zavalaga, Luis Fernando
dc.contributor.author Peralta, Ernesto
dc.contributor.author Valderrama, Gissela
dc.contributor.author Ramos Cordova, Lourdes B.
dc.contributor.author Sanchez Cortez, Lucero I.
dc.contributor.author Rodriguez, German
dc.contributor.author LaHood, Allison N.
dc.contributor.author Franke, Molly F.
dc.contributor.author Mitnick, Carole D.
dc.contributor.author Lecca, Leonid
dc.contributor.author Velásquez, Gustavo E.
dc.coverage.spatial Lima, Perú
dc.date.accessioned 2023-09-06T20:45:07Z
dc.date.available 2023-09-06T20:45:07Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14054
dc.description.abstract BACKGROUND: Few studies have examined the burden of postacute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in low- and middle-income countries. We sought to characterize PASC with self-reported questionnaires and clinical examinations of end-organ function in Lima, Peru. METHODS: From January to July 2021, we recruited participants at least 8 weeks after COVID-19 diagnosis from a case registry in Lima, Peru. We evaluated participants for PASC with questionnaires, neuropsychiatric evaluations, chest X-ray, spirometry, electrocardiogram, and echocardiogram. We used multivariable models to identify risk factors for PASC. RESULTS: We assessed 989 participants for PASC at a median 4.7 months after diagnosis. Clinically significant respiratory symptoms were reported by 68.3% of participants, particularly those who had been severely ill during acute COVID-19, and were associated with cardiac findings of ventricular hypertrophy or dilation on echocardiogram. Neuropsychiatric questionnaires were consistent with depression in 20.7% and cognitive impairment in 8.0%. Female sex and older age were associated with increased risk of respiratory (adjusted odds ratio [aOR], 2.36 [95% confidence interval {CI}, 1.69-3.31] and aOR, 1.01 [95% CI, 1.00-1.03], respectively) and neuropsychiatric sequelae (aOR, 2.99 [95% CI, 2.16-4.18] and aOR, 1.02 [95% CI, 1.01-1.03], respectively). CONCLUSIONS: COVID-19 survivors in Lima, Peru, experienced frequent postacute respiratory symptoms and depression, particularly among older and female participants. Clinical examinations highlighted the need for cardiopulmonary rehabilitation among persons with severe COVID-19; psychosocial support may be required among all COVID-19 survivors. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Open Forum Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject COVID-19 en_US
dc.subject Peru en_US
dc.subject Postacute en_US
dc.subject SARS-CoV-2 en_US
dc.subject Sequelae en_US
dc.subject.mesh COVID-19
dc.subject.mesh Perú
dc.subject.mesh Síndrome Post Agudo de COVID-19
dc.subject.mesh SARS-CoV-2
dc.title Respiratory, Cardiac, and Neuropsychiatric Manifestations of Postacute Sequelae of Coronavirus Disease 2019 in Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/ofid/ofad320
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 2328-8957


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