dc.contributor.author |
Rahman, Rifat S. |
|
dc.contributor.author |
Tovar, Marco A. |
|
dc.contributor.author |
Peinado, Jesús |
|
dc.contributor.author |
Palomino, J. Santiago |
|
dc.contributor.author |
Ramirez, Claudio |
|
dc.contributor.author |
Llanos Zavalaga, Luis Fernando |
|
dc.contributor.author |
Peralta, Ernesto |
|
dc.contributor.author |
Valderrama, Gissela |
|
dc.contributor.author |
Ramos Cordova, Lourdes B. |
|
dc.contributor.author |
Sanchez Cortez, Lucero I. |
|
dc.contributor.author |
Rodriguez, German |
|
dc.contributor.author |
LaHood, Allison N. |
|
dc.contributor.author |
Franke, Molly F. |
|
dc.contributor.author |
Mitnick, Carole D. |
|
dc.contributor.author |
Lecca, Leonid |
|
dc.contributor.author |
Velásquez, Gustavo E. |
|
dc.coverage.spatial |
Lima, Perú |
|
dc.date.accessioned |
2023-09-06T20:45:07Z |
|
dc.date.available |
2023-09-06T20:45:07Z |
|
dc.date.issued |
2023 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/14054 |
|
dc.description.abstract |
BACKGROUND: Few studies have examined the burden of postacute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in low- and middle-income countries. We sought to characterize PASC with self-reported questionnaires and clinical examinations of end-organ function in Lima, Peru. METHODS: From January to July 2021, we recruited participants at least 8 weeks after COVID-19 diagnosis from a case registry in Lima, Peru. We evaluated participants for PASC with questionnaires, neuropsychiatric evaluations, chest X-ray, spirometry, electrocardiogram, and echocardiogram. We used multivariable models to identify risk factors for PASC. RESULTS: We assessed 989 participants for PASC at a median 4.7 months after diagnosis. Clinically significant respiratory symptoms were reported by 68.3% of participants, particularly those who had been severely ill during acute COVID-19, and were associated with cardiac findings of ventricular hypertrophy or dilation on echocardiogram. Neuropsychiatric questionnaires were consistent with depression in 20.7% and cognitive impairment in 8.0%. Female sex and older age were associated with increased risk of respiratory (adjusted odds ratio [aOR], 2.36 [95% confidence interval {CI}, 1.69-3.31] and aOR, 1.01 [95% CI, 1.00-1.03], respectively) and neuropsychiatric sequelae (aOR, 2.99 [95% CI, 2.16-4.18] and aOR, 1.02 [95% CI, 1.01-1.03], respectively). CONCLUSIONS: COVID-19 survivors in Lima, Peru, experienced frequent postacute respiratory symptoms and depression, particularly among older and female participants. Clinical examinations highlighted the need for cardiopulmonary rehabilitation among persons with severe COVID-19; psychosocial support may be required among all COVID-19 survivors. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Oxford University Press |
|
dc.relation.ispartofseries |
Open Forum Infectious Diseases |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
COVID-19 |
en_US |
dc.subject |
Peru |
en_US |
dc.subject |
Postacute |
en_US |
dc.subject |
SARS-CoV-2 |
en_US |
dc.subject |
Sequelae |
en_US |
dc.subject.mesh |
COVID-19 |
|
dc.subject.mesh |
Perú |
|
dc.subject.mesh |
Síndrome Post Agudo de COVID-19 |
|
dc.subject.mesh |
SARS-CoV-2 |
|
dc.title |
Respiratory, Cardiac, and Neuropsychiatric Manifestations of Postacute Sequelae of Coronavirus Disease 2019 in Lima, Peru |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1093/ofid/ofad320 |
|
dc.relation.issn |
2328-8957 |
|