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dc.contributor.author | Rahman, Rifat S. | |
dc.contributor.author | Tovar, Marco A. | |
dc.contributor.author | Peinado, Jesús | |
dc.contributor.author | Palomino, J. Santiago | |
dc.contributor.author | Ramirez, Claudio | |
dc.contributor.author | Llanos Zavalaga, Luis Fernando | |
dc.contributor.author | Peralta, Ernesto | |
dc.contributor.author | Valderrama, Gissela | |
dc.contributor.author | Ramos Cordova, Lourdes B. | |
dc.contributor.author | Sanchez Cortez, Lucero I. | |
dc.contributor.author | Rodriguez, German | |
dc.contributor.author | LaHood, Allison N. | |
dc.contributor.author | Franke, Molly F. | |
dc.contributor.author | Mitnick, Carole D. | |
dc.contributor.author | Lecca, Leonid | |
dc.contributor.author | Velásquez, Gustavo E. | |
dc.coverage.spatial | Lima, Perú | |
dc.date.accessioned | 2023-09-06T20:45:07Z | |
dc.date.available | 2023-09-06T20:45:07Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/14054 | |
dc.description.abstract | BACKGROUND: Few studies have examined the burden of postacute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in low- and middle-income countries. We sought to characterize PASC with self-reported questionnaires and clinical examinations of end-organ function in Lima, Peru. METHODS: From January to July 2021, we recruited participants at least 8 weeks after COVID-19 diagnosis from a case registry in Lima, Peru. We evaluated participants for PASC with questionnaires, neuropsychiatric evaluations, chest X-ray, spirometry, electrocardiogram, and echocardiogram. We used multivariable models to identify risk factors for PASC. RESULTS: We assessed 989 participants for PASC at a median 4.7 months after diagnosis. Clinically significant respiratory symptoms were reported by 68.3% of participants, particularly those who had been severely ill during acute COVID-19, and were associated with cardiac findings of ventricular hypertrophy or dilation on echocardiogram. Neuropsychiatric questionnaires were consistent with depression in 20.7% and cognitive impairment in 8.0%. Female sex and older age were associated with increased risk of respiratory (adjusted odds ratio [aOR], 2.36 [95% confidence interval {CI}, 1.69-3.31] and aOR, 1.01 [95% CI, 1.00-1.03], respectively) and neuropsychiatric sequelae (aOR, 2.99 [95% CI, 2.16-4.18] and aOR, 1.02 [95% CI, 1.01-1.03], respectively). CONCLUSIONS: COVID-19 survivors in Lima, Peru, experienced frequent postacute respiratory symptoms and depression, particularly among older and female participants. Clinical examinations highlighted the need for cardiopulmonary rehabilitation among persons with severe COVID-19; psychosocial support may be required among all COVID-19 survivors. | en_US |
dc.language.iso | eng | |
dc.publisher | Oxford University Press | |
dc.relation.ispartofseries | Open Forum Infectious Diseases | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | COVID-19 | en_US |
dc.subject | Peru | en_US |
dc.subject | Postacute | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | Sequelae | en_US |
dc.subject.mesh | COVID-19 | |
dc.subject.mesh | Perú | |
dc.subject.mesh | Síndrome Post Agudo de COVID-19 | |
dc.subject.mesh | SARS-CoV-2 | |
dc.title | Respiratory, Cardiac, and Neuropsychiatric Manifestations of Postacute Sequelae of Coronavirus Disease 2019 in Lima, Peru | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1093/ofid/ofad320 | |
dc.relation.issn | 2328-8957 |
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