Universidad Peruana Cayetano Heredia

On the importance for drug discovery of a transnational Latin American database of natural compound structures

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dc.contributor.author Thomson Okatsu, Timothy M.
dc.date.accessioned 2023-09-06T20:45:08Z
dc.date.available 2023-09-06T20:45:08Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14069
dc.description.abstract Drug development is a complex, risky, expensive and time-consuming process that requires the accurate execution of multiple stages, from identification and selection of collections of potentially druggable molecules to proof-of-concept validation. Prior to embarking on a drug discovery project, a detailed strategic plan must be designed that includes hundreds of critical considerations such as source of compounds for screening, feasibility of their synthetic pathways, target selection (molecules, cells, organisms), type of output (binding, function, phenotype), throughput, nature, layers and iterations of the screening process, scoring systems, lead optimization approaches or model systems for validation (biochemical activity, cellular function, organismal properties) and, crucially, good contingency plans... en_US
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartofseries Frontiers in Pharmacology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject natural products en_US
dc.subject virtual screening en_US
dc.subject Latin America en_US
dc.subject databases en_US
dc.subject computation en_US
dc.subject.mesh Productos Biológicos
dc.subject.mesh Tamizaje Masivo
dc.subject.mesh América Latina
dc.subject.mesh Bases de Datos como Asunto
dc.title On the importance for drug discovery of a transnational Latin American database of natural compound structures en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3389/fphar.2023.1207559
dc.relation.issn 1663-9812


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