Universidad Peruana Cayetano Heredia

Dog Population Rabies Immunity before a Mass Vaccination Campaign in Lima, Peru: Vulnerabilities for Virus Reestablishment

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dc.contributor.author Chuquista Alcarraz, Olimpia
dc.contributor.author Falcon Perez, Nestor Gerardo
dc.contributor.author Vigilato, Marco A. N.
dc.contributor.author Rocha, Felipe
dc.contributor.author Toledo-Barone, Gisely
dc.contributor.author Amorim-Conselheiro, Juliana
dc.contributor.author Recuenco, Sergio E.
dc.contributor.author Castillo Neyra, Ricardo
dc.coverage.spatial Surquillo, Lima, Perú
dc.date.accessioned 2023-09-06T20:45:09Z
dc.date.available 2023-09-06T20:45:09Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14075
dc.description.abstract Lima, Peru, has not had a case of canine rabies since 1999. However, Lima remains at risk of rabies reintroduction due to the free movement of dogs from nearby rabies-endemic areas. In Latin America, rabies vaccination campaigns must reach 80% of dogs to halt transmission, but estimates of vaccine coverage are often unavailable, unreliable, or inaccurate. Quantifying virus neutralizing antibodies (VNA) allows monitoring of the immunological status of the canine population, evaluation of the degree of humoral protection to the virus, and assessing, partially, the population response to vaccination. We evaluated the dog population's immunity level against the rabies virus before a mass vaccination campaign in Lima. We collected 141 canine blood samples in the district of Surquillo and quantified rabies virus neutralizing antibody titers using the fluorescent antibody virus neutralization test). We surveyed dogs owners to reconstruct canine vaccination histories. Among dogs previously vaccinated, 73.9% exceeded the seroconversion threshold of > 0.5 IU/mL. Among all dogs, only 58.2% reached the titer limit for seroconversion. Dogs ≤ 1 year old constituted 26.2% of the total canine population and had lower levels of VNA than dogs > 1 year old (χ2 = 9.071; P = 0.028). Importantly, dogs vaccinated with single-pathogen vaccines had higher levels of VNA than those who received combined-pathogen vaccines (χ2 = 7.721; P = 0.005). We provide an important and timely glimpse to the immunity status of the dog population in urban areas of Lima, a metropolis near a dog rabies-endemic region. en_US
dc.language.iso eng
dc.publisher American Journal of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Dog en_US
dc.subject Rabies en_US
dc.subject Mass Vaccination Campaign en_US
dc.subject Lima, Peru en_US
dc.subject Virus Reestablishment en_US
dc.subject.mesh Perros
dc.subject.mesh Rabia
dc.subject.mesh Programas de Inmunización
dc.subject.mesh Perú
dc.title Dog Population Rabies Immunity before a Mass Vaccination Campaign in Lima, Peru: Vulnerabilities for Virus Reestablishment en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.22-0530
dc.relation.issn 1476-1645


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