Universidad Peruana Cayetano Heredia
Are trajectories of depressive symptoms during the first half of drug-sensitive pulmonary tuberculosis treatment associated with loss to follow-up? A secondary analysis of longitudinal data
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| dc.contributor.author | Ruiz Grosso, Paulo Jorge Martín | |
| dc.contributor.author | Loret de Mola, Christian | |
| dc.contributor.author | Otero Vegas, Larissa | |
| dc.contributor.author | Ugarte Gil, Cesar Augusto | |
| dc.coverage.spatial | San Juan de Lurigancho, Lima, Perú | |
| dc.date.accessioned | 2023-09-06T20:45:09Z | |
| dc.date.available | 2023-09-06T20:45:09Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/14083 | |
| dc.description.abstract | OBJECTIVE: The objective of this study was to identify trajectories of depressive symptoms (DSs) during the first half of drug-sensitive pulmonary tuberculosis (PTB) treatment and examine their association with loss to follow-up (LTFU) in the second half. DESIGN: This study involved a secondary analysis of longitudinal data to identify potential trajectories of DS and their relationship with LTFU. SETTING: The study was conducted in first and second-level health centres located in San Juan de Lurigancho, Lima, Peru. PARTICIPANTS: Anonymised data from 265 individuals, including monthly measures of DSs from diagnosis to the completion of treatment, initiation of treatment for multidrug resistant TB, LTFU or death, were collected. RESULTS: Three trajectories were identified: 'declining', 'growth' and 'high'. These trajectories were observed in 182 (68.7%), 53 (20%) and 30 (11.3%) of the 265 individuals, respectively, during the first half of PTB treatment. Compared with those with a 'declining' trajectory, individuals with a 'growth' trajectory had a higher likelihood of experiencing LTFU during the second half of PTB treatment, after controlling for sociodemographic factors and at least weekly alcohol use (OR 3.9; 95% CI 1.09 to 13.97, p=0.036). CONCLUSIONS: The findings suggest that a trajectory of increasing DSs during the first half of PTB treatment is associated with a higher risk of LTFU during the second half. | en_US |
| dc.language.iso | eng | |
| dc.publisher | BMJ Group | |
| dc.relation.ispartofseries | BMJ Open | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Depressive symptoms | en_US |
| dc.subject | Drug | en_US |
| dc.subject | Pulmonary tuberculosis | en_US |
| dc.subject | Longitudinal data | en_US |
| dc.subject.mesh | Depresión | |
| dc.subject.mesh | Preparaciones Farmacéuticas | |
| dc.subject.mesh | Tuberculosis Pulmonar | |
| dc.subject.mesh | Análisis de Datos | |
| dc.title | Are trajectories of depressive symptoms during the first half of drug-sensitive pulmonary tuberculosis treatment associated with loss to follow-up? A secondary analysis of longitudinal data | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1136/bmjopen-2022-068235 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.05 | |
| dc.relation.issn | 2044-6055 |
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