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SecretoMyc, a web-based database on mycobacteria secreted proteins and structure-based homology identification using bio-informatics tools

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dc.contributor.author Gracy, Jérôme
dc.contributor.author Vallejos Sanchez, Katherine Jaqueline
dc.contributor.author Cohen-Gonsaud, Martin
dc.date.accessioned 2023-09-06T20:45:11Z
dc.date.available 2023-09-06T20:45:11Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14104
dc.description.abstract To better understand the interaction between the host and the Mycobacterium tuberculosis pathogen, it is critical to identify its potential secreted proteins. While various experimental methods have been successful in identifying proteins under specific culture conditions, they have not provided a comprehensive characterisation of the secreted proteome. We utilized a combination of bioinformatics servers and in-house software to identify all potentially secreted proteins from six mycobacterial genomes through the three secretion systems: SEC, TAT, and T7SS. The results are presented in a database that can be crossed referenced to selected proteomics and transcriptomics studies (https://secretomyc.cbs.cnrs.fr). In addition, thanks to the recent availability of Alphafold models, we developed a tool in order to identify the structural homologues among the mycobacterial genomes. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Tuberculosis
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Secretion en_US
dc.subject Host-pathogen en_US
dc.subject Mycobacteria en_US
dc.subject Alphafold en_US
dc.subject.mesh Secreciones Corporales
dc.subject.mesh Interacciones Huésped-Patógeno
dc.subject.mesh Mycobacterium
dc.title SecretoMyc, a web-based database on mycobacteria secreted proteins and structure-based homology identification using bio-informatics tools en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.tube.2023.102375
dc.relation.issn 1873-281X


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