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Assessment of regional body composition, physical function and sarcopenia among peruvian women aging with HIV: A cross-sectional study.

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dc.contributor.author Cabrera, Diego M.
dc.contributor.author Cornejo, Mijahil P.
dc.contributor.author Pinedo, Yvett
dc.contributor.author Garcia Funegra, Patricia Jannet
dc.contributor.author Hsieh, Evelyn
dc.date.accessioned 2023-10-09T17:09:15Z
dc.date.available 2023-10-09T17:09:15Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14203
dc.description.abstract Management of chronic conditions and optimization of overall health has become a primary global health concern in the care of people living with HIV in the era of highly active antiretroviral therapy (ART), particularly in lower-and-middle income countries where infrastructure for chronic disease management may be fragmented. Alterations in body composition can reflect important changes in musculoskeletal health, particularly among populations at risk for developing fat and muscle redistribution syndromes, such as women with HIV on ART. Given the lack of data on this topic in Latin America and the Caribbean, we designed an exploratory study to measure these outcomes in a population of women aging with HIV in Peru. We conducted a cross-sectional study among Peruvian women with and without HIV aged ≥40 years. Dual X-ray absorptiometry was used to measure trunk and limb lean mass (LM) and fat mass (FM). Physical performance was assessed with the Short Physical Performance Battery (SPPB) and physical strength with a dynamometer. Sarcopenia was assessed based upon EWGSOP criteria. We used linear regression to model associations between body composition, sarcopenia and physical performance scores. 104 women with HIV and 212 women without HIV were enrolled (mean age 52.4±8.2 vs. 56.4±8.8 years, p≤0.001). Among women with HIV, mean years since diagnosis was 11.8±6 and all were on ART. Mean SPPB score was 9.9 vs 10.8 (p<0.001) between both groups. Sarcopenia spectrum was found in 25.9% and 23.1%, respectively. In the multivariable regression analysis, trunk FM and older age were negatively correlated with physical performance among women with HIV. Severe sarcopenia was found among a greater proportion of those with HIV (3.8% vs. 0.9%, p = 0.84), however this finding was not statistically significant. Women with HIV had significantly lower SPPB scores compared to women without HIV, and trunk FM and upper limb LM were independent predictors for the SPPB and Grip Strength tests, respectively. Larger, prospective studies are needed in Latin America & the Caribbean to identify individuals at high risk for sarcopenia and declines in physical function, and to inform prevention guidelines. en_US
dc.language.iso eng
dc.publisher PLoS
dc.relation.ispartofseries PLOS Global Public Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Sarcopenia en_US
dc.subject HIV en_US
dc.subject Body limbs en_US
dc.subject HIV diagnosis and management en_US
dc.subject Hand strength en_US
dc.subject Adipose tissue en_US
dc.subject Medical risk factors en_US
dc.subject Virus testing en_US
dc.title Assessment of regional body composition, physical function and sarcopenia among peruvian women aging with HIV: A cross-sectional study. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pgph.0000814
dc.relation.issn 2767-3375


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