Universidad Peruana Cayetano Heredia

Factors associated with healthy aging in Latin American populations

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dc.contributor.author Santamaria-Garcia, Hernando
dc.contributor.author Sainz-Ballesteros, Agustín
dc.contributor.author Hernandez, Hernán
dc.contributor.author Moguilner, Sebastian
dc.contributor.author Maito, Marcelo
dc.contributor.author Ochoa-Rosales, Carolina
dc.contributor.author Corley, Michael
dc.contributor.author Valcour, Victor
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Lawlor, Brian
dc.contributor.author Ibanez, Agustin
dc.date.accessioned 2023-10-09T17:09:17Z
dc.date.available 2023-10-09T17:09:17Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14219
dc.description.abstract Latin American populations may present patterns of sociodemographic, ethnic and cultural diversity that can defy current universal models of healthy aging. The potential combination of risk factors that influence aging across populations in Latin American and Caribbean (LAC) countries is unknown. Compared to other regions where classical factors such as age and sex drive healthy aging, higher disparity-related factors and between-country variability could influence healthy aging in LAC countries. We investigated the combined impact of social determinants of health (SDH), lifestyle factors, cardiometabolic factors, mental health symptoms and demographics (age, sex) on healthy aging (cognition and functional ability) across LAC countries with different levels of socioeconomic development using cross-sectional and longitudinal machine learning models (n = 44,394 participants). Risk factors associated with social and health disparities, including SDH (β > 0.3), mental health (β > 0.6) and cardiometabolic risks (β > 0.22), significantly influenced healthy aging more than age and sex (with null or smaller effects: β < 0.2). These heterogeneous patterns were more pronounced in low-income to middle-income LAC countries compared to high-income LAC countries (cross-sectional comparisons), and in an upper-income to middle-income LAC country, Costa Rica, compared to China, a non-upper-income to middle-income LAC country (longitudinal comparisons). These inequity-associated and region-specific patterns inform national risk assessments of healthy aging in LAC countries and regionally tailored public health interventions. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Nature Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Neurodegenerative diseases en_US
dc.subject Psychology en_US
dc.title Factors associated with healthy aging in Latin American populations en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/s41591-023-02495-1
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.00.00
dc.relation.issn 1546-170X


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