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Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.

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dc.contributor.author Magnussen, Christina
dc.contributor.author Ojeda, Francisco M.
dc.contributor.author Leong, Darryl P.
dc.contributor.author Alegre-Diaz, Jesus
dc.contributor.author Amouyel, Philippe
dc.contributor.author Aviles-Santa, Larissa
dc.contributor.author De Bacquer, Dirk
dc.contributor.author Ballantyne, Christie M.
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Bobak, Martin
dc.contributor.author Brenner, Hermann
dc.contributor.author Carrillo-Larco, Rodrigo M.
dc.contributor.author de Lemos, James
dc.contributor.author Dobson, Annette
dc.contributor.author Dörr, Marcus
dc.contributor.author Donfrancesco, Chiara
dc.contributor.author Drygas, Wojciech
dc.contributor.author Dullaart, Robin P.
dc.contributor.author Engström, Gunnar
dc.contributor.author Ferrario, Marco M.
dc.contributor.author Ferrières, Jean
dc.contributor.author de Gaetano, Giovanni
dc.contributor.author Goldbourt, Uri
dc.contributor.author Gonzalez, Clicerio
dc.contributor.author Grassi, Guido
dc.contributor.author Hodge, Allison M.
dc.contributor.author Hveem, Kristian
dc.contributor.author Iacoviello, Licia
dc.contributor.author Ikram, M. Kamran
dc.contributor.author Irazola, Vilma
dc.contributor.author Jobe, Modou
dc.contributor.author Jousilahti, Pekka
dc.contributor.author Kaleebu, Pontiano
dc.contributor.author Kavousi, Maryam
dc.contributor.author Kee, Frank
dc.contributor.author Khalili, Davood
dc.contributor.author Koenig, Wolfgang
dc.contributor.author Kontsevaya, Anna
dc.contributor.author Kuulasmaa, Kari
dc.contributor.author Lackner, Karl J.
dc.contributor.author Leistner, David M.
dc.contributor.author Lind, Lars
dc.contributor.author Linneberg, Allan
dc.contributor.author Lorenz, Thiess
dc.contributor.author Lyngbakken, Magnus Nakrem
dc.contributor.author Malekzadeh, Reza
dc.contributor.author Malyutina, Sofia
dc.contributor.author Mathiesen, Ellisiv B.
dc.contributor.author Melander, Olle
dc.contributor.author Metspalu, Andres
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Moitry, Marie
dc.contributor.author Mugisha, Joseph
dc.contributor.author Nalini, Mahdi
dc.contributor.author Nambi, Vijay
dc.contributor.author Ninomiya, Toshiharu
dc.contributor.author Oppermann, Karen
dc.contributor.author d'Orsi, Eleonora
dc.contributor.author Pająk, Andrzej
dc.contributor.author Palmieri, Luigi
dc.contributor.author Panagiotakos, Demosthenes
dc.contributor.author Perianayagam, Arokiasamy
dc.contributor.author Peters, Annette
dc.contributor.author Poustchi, Hossein
dc.contributor.author Prentice, Andrew M.
dc.contributor.author Prescott, Eva
dc.contributor.author Risérus, Ulf
dc.contributor.author Salomaa, Veikko
dc.contributor.author Sans, Susana
dc.contributor.author Sakata, Satoko
dc.contributor.author Schöttker, Ben
dc.contributor.author Schutte, Aletta E.
dc.contributor.author Sepanlou, Sadaf G.
dc.contributor.author Sharma, Sanjib Kumar
dc.contributor.author Shaw, Jonathan E.
dc.contributor.author Simons, Leon A.
dc.contributor.author Söderberg, Stefan
dc.contributor.author Tamosiunas, Abdonas
dc.contributor.author Thorand, Barbara
dc.contributor.author Tunstall-Pedoe, Hugh
dc.contributor.author Twerenbold, Raphael
dc.contributor.author Vanuzzo, Diego
dc.contributor.author Veronesi, Giovanni
dc.contributor.author Waibel, Julia
dc.contributor.author Wannamethee, S. Goya
dc.contributor.author Watanabe, Masafumi
dc.contributor.author Wild, Philipp S.
dc.contributor.author Yao, Yao
dc.contributor.author Zeng, Yi
dc.contributor.author Ziegler, Andreas
dc.contributor.author Blankenberg, Stefan
dc.date.accessioned 2023-10-09T17:09:17Z
dc.date.available 2023-10-09T17:09:17Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14222
dc.description.abstract BACKGROUND: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking. METHODS: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality. RESULTS: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6). CONCLUSIONS: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. en_US
dc.language.iso eng
dc.publisher Massachusetts Medical Society
dc.relation.ispartofseries New England Journal of Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Modifiable Risk Factors en_US
dc.subject Cardiovascular Disease en_US
dc.subject Mortality en_US
dc.title Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1056/NEJMoa2206916
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 1533-4406


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