dc.contributor.author |
Magnussen, Christina |
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dc.contributor.author |
Ojeda, Francisco M. |
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dc.contributor.author |
Leong, Darryl P. |
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dc.contributor.author |
Alegre-Diaz, Jesus |
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dc.contributor.author |
Amouyel, Philippe |
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dc.contributor.author |
Aviles-Santa, Larissa |
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dc.contributor.author |
De Bacquer, Dirk |
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dc.contributor.author |
Ballantyne, Christie M. |
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dc.contributor.author |
Bernabé Ortiz, Antonio |
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dc.contributor.author |
Bobak, Martin |
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dc.contributor.author |
Brenner, Hermann |
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dc.contributor.author |
Carrillo-Larco, Rodrigo M. |
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dc.contributor.author |
de Lemos, James |
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dc.contributor.author |
Dobson, Annette |
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dc.contributor.author |
Dörr, Marcus |
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dc.contributor.author |
Donfrancesco, Chiara |
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dc.contributor.author |
Drygas, Wojciech |
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dc.contributor.author |
Dullaart, Robin P. |
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dc.contributor.author |
Engström, Gunnar |
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dc.contributor.author |
Ferrario, Marco M. |
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dc.contributor.author |
Ferrières, Jean |
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dc.contributor.author |
de Gaetano, Giovanni |
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dc.contributor.author |
Goldbourt, Uri |
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dc.contributor.author |
Gonzalez, Clicerio |
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dc.contributor.author |
Grassi, Guido |
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dc.contributor.author |
Hodge, Allison M. |
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dc.contributor.author |
Hveem, Kristian |
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dc.contributor.author |
Iacoviello, Licia |
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dc.contributor.author |
Ikram, M. Kamran |
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dc.contributor.author |
Irazola, Vilma |
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dc.contributor.author |
Jobe, Modou |
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dc.contributor.author |
Jousilahti, Pekka |
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dc.contributor.author |
Kaleebu, Pontiano |
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dc.contributor.author |
Kavousi, Maryam |
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dc.contributor.author |
Kee, Frank |
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dc.contributor.author |
Khalili, Davood |
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dc.contributor.author |
Koenig, Wolfgang |
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dc.contributor.author |
Kontsevaya, Anna |
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dc.contributor.author |
Kuulasmaa, Kari |
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dc.contributor.author |
Lackner, Karl J. |
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dc.contributor.author |
Leistner, David M. |
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dc.contributor.author |
Lind, Lars |
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dc.contributor.author |
Linneberg, Allan |
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dc.contributor.author |
Lorenz, Thiess |
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dc.contributor.author |
Lyngbakken, Magnus Nakrem |
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dc.contributor.author |
Malekzadeh, Reza |
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dc.contributor.author |
Malyutina, Sofia |
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dc.contributor.author |
Mathiesen, Ellisiv B. |
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dc.contributor.author |
Melander, Olle |
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dc.contributor.author |
Metspalu, Andres |
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dc.contributor.author |
Miranda, J. Jaime |
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dc.contributor.author |
Moitry, Marie |
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dc.contributor.author |
Mugisha, Joseph |
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dc.contributor.author |
Nalini, Mahdi |
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dc.contributor.author |
Nambi, Vijay |
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dc.contributor.author |
Ninomiya, Toshiharu |
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dc.contributor.author |
Oppermann, Karen |
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dc.contributor.author |
d'Orsi, Eleonora |
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dc.contributor.author |
Pająk, Andrzej |
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dc.contributor.author |
Palmieri, Luigi |
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dc.contributor.author |
Panagiotakos, Demosthenes |
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dc.contributor.author |
Perianayagam, Arokiasamy |
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dc.contributor.author |
Peters, Annette |
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dc.contributor.author |
Poustchi, Hossein |
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dc.contributor.author |
Prentice, Andrew M. |
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dc.contributor.author |
Prescott, Eva |
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dc.contributor.author |
Risérus, Ulf |
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dc.contributor.author |
Salomaa, Veikko |
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dc.contributor.author |
Sans, Susana |
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dc.contributor.author |
Sakata, Satoko |
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dc.contributor.author |
Schöttker, Ben |
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dc.contributor.author |
Schutte, Aletta E. |
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dc.contributor.author |
Sepanlou, Sadaf G. |
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dc.contributor.author |
Sharma, Sanjib Kumar |
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dc.contributor.author |
Shaw, Jonathan E. |
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dc.contributor.author |
Simons, Leon A. |
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dc.contributor.author |
Söderberg, Stefan |
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dc.contributor.author |
Tamosiunas, Abdonas |
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dc.contributor.author |
Thorand, Barbara |
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dc.contributor.author |
Tunstall-Pedoe, Hugh |
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dc.contributor.author |
Twerenbold, Raphael |
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dc.contributor.author |
Vanuzzo, Diego |
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dc.contributor.author |
Veronesi, Giovanni |
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dc.contributor.author |
Waibel, Julia |
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dc.contributor.author |
Wannamethee, S. Goya |
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dc.contributor.author |
Watanabe, Masafumi |
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dc.contributor.author |
Wild, Philipp S. |
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dc.contributor.author |
Yao, Yao |
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dc.contributor.author |
Zeng, Yi |
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dc.contributor.author |
Ziegler, Andreas |
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dc.contributor.author |
Blankenberg, Stefan |
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dc.date.accessioned |
2023-10-09T17:09:17Z |
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dc.date.available |
2023-10-09T17:09:17Z |
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dc.date.issued |
2023 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12866/14222 |
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dc.description.abstract |
BACKGROUND: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking. METHODS: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality. RESULTS: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6). CONCLUSIONS: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. |
en_US |
dc.language.iso |
eng |
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dc.publisher |
Massachusetts Medical Society |
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dc.relation.ispartofseries |
New England Journal of Medicine |
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dc.rights |
info:eu-repo/semantics/restrictedAccess |
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dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
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dc.subject |
Modifiable Risk Factors |
en_US |
dc.subject |
Cardiovascular Disease |
en_US |
dc.subject |
Mortality |
en_US |
dc.title |
Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. |
en_US |
dc.type |
info:eu-repo/semantics/article |
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dc.identifier.doi |
https://doi.org/10.1056/NEJMoa2206916 |
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dc.relation.issn |
1533-4406 |
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