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Prussian blue (PB) modified gold nanoparticles as a SERS-based sensing platform for capturing and detection of pyrazinoic acid (POA).

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dc.contributor.author Liu, Chen
dc.contributor.author Jiménez Avalos, Gabriel Mateo
dc.contributor.author Zhang, Wen-Shu
dc.contributor.author Sheen Cortavarria, Patricia
dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Popp, Jürgen
dc.contributor.author Cialla-May, Dana
dc.date.accessioned 2023-10-09T17:09:19Z
dc.date.available 2023-10-09T17:09:19Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14240
dc.description.abstract Pyrazinoic acid (POA) is a metabolite of the anti-tuberculosis drug pyrazinamide (PZA), and its detection can be used to assess the resistance of Mycobacterium tuberculosis in cultures, as only sensitive strains of the bacteria can metabolize PZA into POA. Prussian blue is a well-known metal-organic framework compound widely used in various sensing platforms such as electrochemical, photochemical, and magnetic sensors. In this study, we present a novel sensing platform based on Prussian blue-modified gold nanoparticles (AuNPs) designed to enhance the affinity of POA towards the sensing surface and to capture POA molecules from aqueous solutions. This SERS-based method allows for the selective enrichment of POA, which can be detected in both pure aqueous solution and in the presence of its pro-drug PZA. The limit of detection (LOD) for POA was estimated to be 1.08 μM in pure aqueous solution and 0.18 mM in the presence of PZA. Furthermore, the precision of the SERS method was verified by the relative standard deviation (RSD) of 3.34-12.02% for three parallel samples using different matrices, i.e. aqueous solution, spiked river water and spiked simulated saliva. The recoveries of the samples ranged from 92.65 to 118.51%. These all demonstrate the potential application of the proposed detection scheme in medical research. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Talanta
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Pyrazinoic acid (POA) en_US
dc.subject Surface enhanced Raman spectroscopy (SERS) en_US
dc.subject Prussian blue en_US
dc.subject Gold nanoparticles en_US
dc.subject Quantitative analysis en_US
dc.title Prussian blue (PB) modified gold nanoparticles as a SERS-based sensing platform for capturing and detection of pyrazinoic acid (POA). en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.talanta.2023.125038
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.07
dc.relation.issn 1873-3573


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