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Transferable mechanisms of quinolone resistance are more frequent among enterotoxigenic Escherichia coli isolates displaying low-level quinolone resistance

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dc.contributor.author Medina Prada, Anicia Magaly
dc.contributor.author Rivera Albinagorta, Fulton Paul
dc.contributor.author Riveros Ramirez, Maribel Denise
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Pons, M.J.
dc.contributor.author Ruiz, J.
dc.date.accessioned 2023-10-09T17:09:20Z
dc.date.available 2023-10-09T17:09:20Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14246
dc.description.abstract This study analysed the mechanisms of quinolone resistance among enterotoxigenic Escherichia coli (ETEC) in a periurban area of Lima, Peru. The susceptibility to nalidixic acid and ciprofloxacin, the role of Phe-Arg-b-Naphtylamyde inhibitable-(PAbN) efflux pumps, the presence of mutations in gyrA and parC as well as the presence of aac(6’)Ib-cr, qepA, qnrA, qnrB, qnrC, qnrD, qnrVC and oqxAB were determined in 31 ETEC from previous case/control studies of children’s diarrhoea. Discordances between disk diffusion, with all isolates showing intermediate or fully resistance to nalidixic acid, and minimal inhibitory concentration (MIC), with 7 isolates being below considered resistance breakpoint, were observed. Twenty-one isolates possessed gyrA mutations (19 S83L, 2 S83A). AAC(6’) Ib-cr, QnrS, QnrB and QepA were found in 7, 6, 2 and 1 isolates respectively, with 3 isolates presenting 2 transferable mechanisms of quinolone resistance (TMQR) concomitantly. TMQR were more frequent among isolates with MIC to nalidixic acid ranging from 2 to 16 mg/L (p=0.03), while gyrA mutations were more frequent among isolates with nalidixic acid MIC > 128 mg/L (p=0.0002). In summary, the mechanisms of quinolone resistance present in ETEC isolates in Peru have been described. Differences in the prevalence of underlying mechanisms associated with final MIC levels were observed. The results suggest two different evolutive strategies to survive in the presence of quinolones related to specific bacterial genetic background. en_US
dc.description.sponsorship Este trabajo fue financiado por FONDECYT [número de contrato 08-2019]. es_PE
dc.language.iso eng
dc.publisher The Malaysian Society of Parasitology and Tropical Medicine
dc.relation.ispartofseries Tropical Biomedicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Epidemiology en_US
dc.subject Public health en_US
dc.subject GyrA en_US
dc.subject Qnr en_US
dc.subject Diarrheogenic Escherichia coli en_US
dc.title Transferable mechanisms of quinolone resistance are more frequent among enterotoxigenic Escherichia coli isolates displaying low-level quinolone resistance en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.47665/tb.40.2.009
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 2521-9855


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