Universidad Peruana Cayetano Heredia

Liver transplant in primary sclerosing cholangitis: Current trends and future directions

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dc.contributor.author Shah, Yash R.
dc.contributor.author Nombera Aznaran, Natalia Roxana
dc.contributor.author Guevara Lazo, David Rafael
dc.contributor.author Calderon-Martinez, Ernesto
dc.contributor.author Tiwari, Angad
dc.contributor.author Kanumilli, SriLakshmiDevi
dc.contributor.author Shah, Purva
dc.contributor.author Pinnam, Bhanu Siva Mohan
dc.contributor.author Ali, Hassam
dc.contributor.author Dahiya, Dushyant Singh
dc.date.accessioned 2023-10-12T15:30:08Z
dc.date.available 2023-10-12T15:30:08Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14285
dc.description.abstract Primary sclerosing cholangitis (PSC) is a chronic and progressive immunemediated cholangiopathy causing biliary tree inflammation and scarring, leading to liver cirrhosis and end-stage liver disease. Diagnosis of PSC is challenging due to its nonspecific symptoms and overlap with other liver diseases. Despite the rising incidence of PSC, there is no proven medical therapy that can alter the natural history of the disease. While liver transplantation (LT) is the most effective approach for managing advanced liver disease caused by PSC, post-transplantation recurrence of PSC remains a challenge. Therefore, ongoing research aims to develop better therapies for PSC, and continued efforts are necessary to improve outcomes for patients with PSC. This article provides an overview of PSC’s pathogenesis, clinical presentation, and management options, including LT trends and future aspects. It also highlights the need for improved therapeutic options and ethical considerations in providing equitable access to LT for patients with PSC. Additionally, the impact of liver transplant on the quality of life and psychological outcomes of patients with PSC is discussed. Ongoing research into PSC’s pathogenesis and post-transplant recurrence is crucial for improved understanding of the disease and more effective treatment options. en_US
dc.language.iso eng
dc.publisher Baishideng Publishing Group
dc.relation.ispartofseries World Journal of Hepatology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Primary sclerosing cholangitis en_US
dc.subject Liver transplantation en_US
dc.subject Management en_US
dc.subject Psychosocial outcomes en_US
dc.subject Pathogenesis en_US
dc.subject.mesh Colangitis Esclerosante
dc.subject.mesh Trasplante de Hígado
dc.subject.mesh Patogénesis Homeopática
dc.title Liver transplant in primary sclerosing cholangitis: Current trends and future directions en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4254/wjh.v15.i8.939
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.19
dc.relation.issn 1948-5182


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