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Prevalence of Antimicrobial Resistance in Gram-Negative Bacteria Bloodstream Infections in Peru and Associated Outcomes: VIRAPERU Study.

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dc.contributor.author Krapp Lopez, Fiorella del Carmen
dc.contributor.author García Apac, Coralith Marlinda
dc.contributor.author Hinostroza, Noemi
dc.contributor.author Astocondor Gamarra, Aurora Lizeth
dc.contributor.author Rondon Paz, Claudia Rossana
dc.contributor.author Ingelbeen, Brecht
dc.contributor.author Alpaca-Salvador, Hugo A.
dc.contributor.author Amaro Giraldo, Catherine Leonor
dc.contributor.author Aguado Ventura, Carla
dc.contributor.author Barco-Yaipén, Evelyn
dc.contributor.author Bocangel Fernandez, Cesar
dc.contributor.author Briones, Alexander
dc.contributor.author Burgos, Antonio
dc.contributor.author Campana, Rene
dc.contributor.author Castillo, Kelly
dc.contributor.author Castañeda-Sabogal, Alex
dc.contributor.author Coaquira, Angelica
dc.contributor.author Concha-Velasco, Fátima
dc.contributor.author Cuadros, Edwin Cuaresma
dc.contributor.author Chincha Lino, Omayra Jannet
dc.contributor.author Diaz, Juan Carlos
dc.contributor.author Díaz Sipión, Roberto
dc.contributor.author Fernandez, Victor
dc.contributor.author Hueda-Zavaleta, Miguel
dc.contributor.author López, Enrique
dc.contributor.author Valera-Krumdieck, María
dc.contributor.author Vásquez, Rubén
dc.contributor.author Vidaurre Torres, Ana María
dc.contributor.author Villegas-Chiroque, Miguel
dc.contributor.author Sarmiento Lopez, Favio
dc.contributor.author Sullón Zavaleta, Pedro Alberto
dc.contributor.author Sierra Chavez, Elizett
dc.contributor.author Paricahua Peralta, Eduardo
dc.contributor.author Peralta Córdova, Teresa
dc.contributor.author Pino-Dueñas, Jimena Edith
dc.contributor.author Jacobs, Jan
dc.date.accessioned 2023-10-12T15:30:08Z
dc.date.available 2023-10-12T15:30:08Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14291
dc.description.abstract Surveillance of antimicrobial resistance among gram-negative bacteria (GNB) is of critical importance, but data for Peru are not available. To fill this gap, a non-interventional hospital-based surveillance study was conducted in 15 hospitals across Peru from July 2017 to October 2019. Consecutive unique blood culture isolates of key GNB (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter spp.) recovered from hospitalized patients were collected for centralized antimicrobial susceptibility testing, along with linked epidemiological and clinical data. A total of 449 isolates were included in the analysis. Resistance to third-generation cephalosporins (3GCs) was present in 266 (59.2%) GNB isolates. Among E. coli (n = 199), 68.3% showed 3GC resistance (i.e., above the median ratio for low- and middle-income countries in 2020 for this sustainable development goal indicator). Carbapenem resistance was present in 74 (16.5%) GNB isolates, with wide variation among species (0% in E. coli, 11.0% in K. pneumoniae, 37.0% in P. aeruginosa, and 60.8% in Acinetobacter spp. isolates). Co-resistance to carbapenems and colistin was found in seven (1.6%) GNB isolates. Empiric treatment covered the causative GNB in 63.3% of 215 cases. The in-hospital case fatality ratio was 33.3% (92/276). Pseudomonas aeruginosa species and carbapenem resistance were associated with higher risk of in-hospital death. In conclusion, an important proportion of bloodstream infections in Peru are caused by highly resistant GNB and are associated with high in-hospital mortality. en_US
dc.language.iso eng
dc.publisher American Journal of Tropical Medicine and Hygiene
dc.relation.ispartofseries The American Journal of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Antimicrobial Resistance en_US
dc.subject Gram-Negative Bacteria en_US
dc.subject Bloodstream en_US
dc.subject Infections en_US
dc.subject Peru en_US
dc.subject.mesh Farmacorresistencia Microbiana
dc.subject.mesh Bacterias Gramnegativas
dc.subject.mesh Sepsis
dc.subject.mesh Infecciones
dc.subject.mesh Perú
dc.title Prevalence of Antimicrobial Resistance in Gram-Negative Bacteria Bloodstream Infections in Peru and Associated Outcomes: VIRAPERU Study. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.22-0556
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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