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Antibiotic point prevalence survey and antimicrobial resistance in hospitalized patients across Peruvian reference hospitals.

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dc.contributor.author Rondon Paz, Claudia Rossana
dc.contributor.author García Apac, Coralith Marlinda
dc.contributor.author Krapp Lopez, Fiorella del Carmen
dc.contributor.author Machaca, Isela
dc.contributor.author Olivera, Marco
dc.contributor.author Fernández, Victor
dc.contributor.author Villegas, Miguel
dc.contributor.author Vilcapoma, Pierina
dc.contributor.author Casapia, Martin
dc.contributor.author Concha-Velasco, Fátima
dc.contributor.author Díaz, Juan C.
dc.contributor.author Sarmiento, Favio
dc.contributor.author Guillermo, Rosa
dc.contributor.author Farnham, Andrea
dc.contributor.author Sutter, Sarah T.
dc.contributor.author Kuenzli, Esther
dc.coverage.spatial Lima, Perú
dc.date.accessioned 2023-12-05T17:47:57Z
dc.date.available 2023-12-05T17:47:57Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14610
dc.description.abstract BACKGROUND: Peru reports higher levels than other countries in Latin America of resistance to antimicrobials among Gram-positive and Gram-negative bacteria, however data on antibiotic use in Peru are scarce. This study aims to estimate the prevalence and quality of antibiotic prescription in hospitalized patients and to determine the antibiotic susceptibility rates of bacteria causing key bacterial infections. METHODS: We carried out a point prevalence survey of antibiotic prescription at ten public hospitals in nine regions of Peru. Data was collected from patients hospitalized during a 3-week period, with details about antibiotic use, patient information, and antimicrobial susceptibility. RESULTS: 1620 patient charts were reviewed; in 924 cases antibiotics were prescribed (57.0 %, range 45.9-78.9 %). Most of the antibiotics (74.2 %) were prescribed as empirical treatment, only 4.4 % as targeted treatment. For 9.5 % of cases the reason for antibiotic use was unknown. Cephalosporins were the most prescribed (30.0 %), followed by carbapenems (11.3 %). Ninety-four blood cultures were positive for bacterial growth, 48.8 % of the Staphylococcus aureus were methicillin-resistant, among Escherichia coli and Klebsiella pneumoniae, 51.7 % and 72.7 % were resistant to third-generation cephalosporins (3GC), 3.4 % and 18.2 % were resistant to carbapenems, respectively. Among bacteria isolated from urine cultures (n = 639), 43.9 % of E. coli and 49.2 % of K. pneumoniae were resistant to 3GC, and 0.9 % of E. coli and 3.2 % of K. pneumoniae were resistant to meropenem. CONCLUSIONS: The overall proportion of hospitalized patients receiving antibiotics in hospitals from different regions in Peru was high, with only a small proportion receiving targeted treatment. Cephalosporins and carbapenems were the most frequently prescribed antibiotics, reflecting high resistance rates against 3GC and carbapenems in Enterobacterales isolated from blood and urine. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Infection and Public Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Drug resistance en_US
dc.subject Point prevalence survey en_US
dc.subject Antibiotic en_US
dc.subject.mesh Resistencia a Medicamentos
dc.subject.mesh Prevalencia
dc.subject.mesh Antibacterianos
dc.title Antibiotic point prevalence survey and antimicrobial resistance in hospitalized patients across Peruvian reference hospitals. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jiph.2023.10.030
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1876-035X


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